51) Int. Cl." ...................... C12P 21/00; C12N 15/00; C12N 1/00; A61K 39/00 52 U.S. Cl. ................................... 435/68; 435/172.3; 435/253; 435/317; 514/8; 514/12; 530/350; 530/351; 530/395; 530/808; 424/85; 424/88; 536/27 58) Field of Search ................... 435/68, 70,240, 243, 435/253, 172.3, 317; 514/12, 8; 260/112.5 R; 935/9, 11-13, 65; 536/27; 424/88, 85; 530/350, 35...

The aim of the present study was to investigate the antiproliferative effects of interferon (IFN)-α and rapamycin (RPM) on renal cell carcinoma (RCC) cells and examine the synergistic growth suppression conferred by IFN-α and RPM. The effects of IFN-α and/or RPM on RCC cells were determined using a WST-1 assay and the synergy of IFN-α and RPM against three RCC cell lines was analyzed with isobo...

We report on the design and performance of a 530-GHz balanced SIS mixer, the first balanced mixer in this frequency range. This quasi-optical balanced mixer utilizes a cross-slot antenna on a hyperhemispherical substrate lens with eight superconductor–insulator–superconductor (SIS) junctions and a 180 lumped element IF hybrid circuit. The local oscillator (LO) and the radio frequency (RF) signa...

Address correspondence to Ken Naka, NYU Medical Center, 550 First Avenue, PHL-821, New York, NY 10016. J. G~N. I'~S~OL 9 The Rockefeller University Press 9 0022-1295/95/06/0795/20 $2.00 Volume 105 June 1995 795-814 795 on A ril 6, 2016 jgp.rress.org D ow nladed fom Published June 1, 1995

BACKGROUND Among patients with implantable defibrillators (ICD), use of remote patient monitoring (RPM) is associated with lower risk of death and rehospitalization. Standard ICD RPM can be supplemented with weight and blood pressure data. It is not known whether standard RPM plus routine weight and blood pressure transmission (RPM+) is associated with better outcomes. METHODS AND RESULTS RPM...

In guinea pig auditory cortex, two core areas, a primary area (AI) and a dorsocaudal field (DC), and two belt regions ventral to AI and DC (VRB and VCB) with an intermediate zone (T) in between, together with a small field (S) rostral to AI, have been reported in single-electrode studies although field S and zone T have not been observed in imaging studies. Using a high-resolution in vivo optic...

Mentoring is an essential catalyst for a successful medical career in science or clinical practice. In recent years, tools have been developed to measure the impact of mentoring on career achievements, and numerous models have been developed to improve mentor training. Sid Gilman, M.D., F.R.C.P., Chair of Neurology for 26 years at the University of Michigan, is well-recognized as a role model f...