Background/Aim: Alzheimer's disease is a progressive disorder that causes atrophy and neuronal death in the brain. Currently, there not any effective therapy for disease. The current research was designed to investigate beneficial effects of allicin on Alzheimer’s SHSY-5Y cells vitro elucidating neuroprotective mechanism allicin. Methods: Human neuroblastoma cell line (SH-SY5Y) differentiated w...

BACKGROUND to evaluate the role of a risk stratification system in intermediate-risk prostate cancer (PCa) treated with hypofractionated radiotherapy (HyRT). METHODS 131 patients affected by intermediate-risk PCa were treated with HyRT at the total dose of 54,75 Gy in 15 fraction plus 9 months of androgen deprivation therapy (ADT). Patients were classified as favourable risk (FIR) if they had...

BACKGROUND Increased 5-y survival for screened patients is often inferred to mean that fewer patients die of cancer. However, due to several biases, the 5-y survival rate is a misleading metric for evaluating a screening's effectiveness. If physicians are not aware of these issues, informed screening counseling cannot take place. METHODS Two questionnaire versions ("group" and "time") present...

Monoamine oxidases (EC 1.4.3.4; MAOs), a family of FAD-containing enzymes, is an important target for antidepressant drugs. In this paper, a series of 2-phenoxyacetamide analogues were synthesized, and their inhibitory potency towards monoamine oxidases A (MAO-A) and B (MAO-B) were evaluated using enzyme and cancer cell lysate. 2-(4-Methoxyphenoxy)acetamide (compound 12) (SI=245) and (2-(4-((pr...

This study evaluated the effects of sintering temperature on Vickers microhardness and three-point flexural strength values two multi-layered zirconia materials. Multi-layered systems with four distinct layers were selected: DD cube ONE ML (4Y-TZP) cubeX2 (5Y-TZP). In total, 96 plate-shaped A2-shade specimens obtained using individual these The then divided equally into batches three different ...

The objective of the present study was to characterize the liver oil extracted from the deep sea shark, Echinorhinus brucus, caught from Central Indian Ocean and to evaluate its cytotoxic effect on neuroblastoma cell line (SHSY-5Y). Characterization of liver oil of Echinorhinus brucus revealed the presence of palmitic acid (15%), oleic acid (12%), stearic acid (8%), docosahexaenoic acid (DHA) (...