diazotization of 3-amino-2-cmoro pyridine (3) in the presence of dithizone (5) gave dphenyl-2-phenylazo-4h-pyrid[o3 ,2-e] [1,3,4] thiadiazine (6). reaction of 2- chloro-3-nitropyridine (2, g=h) with (5) dfordd 4-phenyl -2-phenylazo -4hpyrido [2,3-el [1,3,4] thiadiazine (7). reduction of the latter with h gas in the presence of raney nickel gave the corresponding amino derivative (12). one pot c...

the aim of the present study was determination of reference values of blood serum enzymes of huso huso. descriptive study. 18 male and 18 female huso huso was studied. blood samples were obtained from caudal vein of 18 males and 18 females and the levels of enzymes were measured by an autoanalyzer. parametric t- test and pearson correlation test. results of measurements for total samples are as...

Two efficient and practical methods of synthesis of the C-10 substituent of DV-7751 (1), a novel quinolone carboxylic acid, were established. The first method utilizes an optical resolution of racemic 8-amino-6-benzyl-6-azaspiro[3.4]octane (13), while the second employs an enantioselective microbial reduction of 6-benzyl-5,8-dioxo-6-azaspiro[3.4]octane (8b). The enantiomeric excess of (S)-8-ami...

1,1,2-trimethyl-1H-benzo[e]indole is an important heterocyclic compound, its available in reasonable price and can easily modified to make a good intermediate for other derivatives. That quite enough reasons use as starting material new series of compounds with biomolecules such monosaccharides after simple modification. The target molecules show biological activity. So, the current work aiming...

Abstract A series of new quinazoline-4(3H)-one derivatives (2-16) have been synthesized using methyl α-[(4-oxoquinazolin-2-yl)thio]acetate (1) as precursor. The corresponding hydrazide (2) and thiosemicarbazide (4) were from this ester via the reaction with hydrazine hydrate ammonium thiocyanate respectively. was employed to synthesize 2-amino-1,3,4-thiadiazole (5) 1,3,4-triazole-5-thiol (6) it...

1Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, USA 2Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA 3Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY, USA 4Center for Immunotherapy, Roswell Park Cancer Institute, Buffalo, NY, USA *Present address: Eppley Institute for Research in Cancer, Universit...