OBJECTIVE Insulin resistance (IR) in older individuals is associated with risk factors for coronary artery disease. The glucose clamp measures IR directly, but the homeostasis model assessment (HOMA) of IR, referred to here as HOMA-IR, is based on fasting glucose and insulin and is less invasive and labor intensive. This method requires validation in the elderly. RESEARCH DESIGN AND METHODS W...

Background. To assess fasting C-peptide and insulin indices using homeostatic model assessment (HOMA) in gestational diabetes mellitus (GDM). Methods. Gestational (n = 64, age: 27.02 ± 0.53 years, BMI: 26.3 0.5 kg/m2; mean SEM) normal glucose tolerance NGT 56, 26.11 0.55 24.4 0.4 screened according to WHO 2013 criteria. Glucose was measured by oxidase method whereas ELISA. HOMA-IR, HOMA-B HOMA-...

BACKGROUND/AIMS Chronic hepatitis C virus (HCV) infection is associated with a higher risk of the development of insulin resistance. If HCV is a causal factor for insulin resistance, then clearance of HCV might decrease insulin resistance. The aim of this study was to elucidate the effects of clearance of HCV on insulin resistance. METHODS We analyzed 28 patients with HCV infection who receiv...

[Purpose] This study aimed to examine the correlation of visfatin level to pancreatic endocrine hormone level, homeostasis model assessment of insulin resistance (HOMA-IR) index, and HOMA β-cell index in hydraulic resistance exercise. Furthermore, it investigated the relationship between visfatin level and other variables affected by exercise in overweight women. [Subjects and Methods] The exer...

OBJECTIVE To evaluate the effects of periodontal intervention on inflammatory cytokines, adiponectin, insulin resistance (IR), and metabolic control and to investigate the relationship between type 2 diabetes mellitus (T2DM) and moderately poor glycemic control and chronic periodontitis. METHODS AND PATIENTS A total of 190 moderately poorly controlled (HbA1c between 7.5% and 9.5%) T2DM patien...

BACKGROUND Neighboring genes PIK3CA and KCNMB3 are both important for insulin signaling and β-cell function, but their associations with glucose-related traits are unclear. OBJECTIVE The objective was to examine associations of PIK3CA-KCNMB3 variants with glucose-related traits and potential interaction with dietary fat. DESIGN We first investigated genetic associations and their modulation...

Background. Insulin resistance indices, in particular homeostatic model assessment of insulin (HOMA-IR), and circulating cytokines are promising markers for noninvasive hepatocyte damage metabolic risk non-alcoholic fatty liver disease (NAFLD) children can be used to select pediatric patients at adverse course. The purpose was determine the diagnostic accuracy children. Materials methods. One h...