Serum angiotensin-converting enzyme (ACE) is elevated in many patients with pulmonary sarcoidosis and has been proposed as a measure of disease activity. The present study was designed to evaluate the possible relationship between serum ACE and direct measures of the intensity of the alveolitis of pulmonary sarcoidosis as measured by bronchoalveolar lavage and gallium-67 (67Ga) scans. To accomp...

the radioisotope 67ga (t 1/2 = 78 h) in extensively used as single photon marker for detecting the presence of malignancy and the diagnosis of inflammatory diseases. the high tumor specificity of carrier-free 67ga make it one of the most interesting radionuclides in nuclear medicine for in vivo scanning studies.67ga is a cyclotron produced radioisotopes and is one of the radiopharmaceuticals wh...

67gallium-bleomycin complex (67ga-blm) was prepared using thakour method. radio-thin-layer-chromatography of prepared complex showed a2 and b2 radiopeaks with rf at 0.7 and 0.4 respectively with a purity of above % 95. tissue uptake of 67ga-blm and 67gacl3 in twelve tissues including tumor, blood, liver, lung, spleen, muscle, skin, heart, kidney, colon, colon content ,bladder and the total body...

fractionation techniques, investigators at Oak Ridge (4, 16, 20) have identified "lysosomal-like" granules as the primary sites of 67Ga localization of AKR/J leukemia, RFT rat fibrosarcoma, mouse lymphosarcoma, and Morris hepatoma cells, as well as a number of normal cells including liver cells, Kupffer cells, parenchymal cells, thymic epithe lial reticular cells, and epithelium cells of renal ...

For the establishment of the experimental system to judge easily the effect of anti-inflammatory drug, 67Ga-citrate was used. The weight of granuloma tissues induced by inflammable agent, turpentine oil, gradually increased and reached a maximum at 6 days after the administration of turpentine oil. Gallium-67 accumulation in the inflammatory lesions showed also a maximum at 6 days after that. B...

The uptake of 67Gaby HL60 cells requires binding of 67Ga-transferrin (TO to cell surface Tf receptors. To further examine this process, we have studied early events in the cellular uptake of 67GaTf. Cell surfacebound "~(.;i11 and '"loll displayed similar kinetics during the first 10 min of uptake. Thereafter, approximately 10% of intracellular 67Gawas released by cells while 59Fe internalizatio...

Background Radiolabeled phosphatidylserine (PS)-binding peptides represent an innovative strategy for molecular imaging of apoptosis and thrombus. The hexapeptide PGDLSR was described as a selective and high affinity ligand for PS. In this work, we synthesized and evaluated a gallium labelled-PGDLSR peptide as a potential and selective radiopharmaceutical for nuclear imaging. PGDLSR-β-alanine-N...

Immunoglobulin (Ig) levels increase in the lower respiratory tract of patients with pulmonary sarcoidosis. We evaluated the effects of prednisone therapy upon Ig concentrations in bronchoalveolar lavage (BAL) fluid of ten patients with active disease (greater than 30% T-lymphocytes in BAL and positive 67Gallium (67Ga) lung scan). Therapy significantly lowered T-lymphocyte percentages in BAL and...