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heterocycles. Substitution reactions of 1(2H)-isoquinolone derivatives have been reported, however, little attention has been focused on addition reactions. Dyke et al. reported a Diels–Alder (DA) reaction of 2-methyl-1(2H)-isoquinolone derivatives as the diene. To the best of our knowledge, however, there have been no reports of a DA reaction of 1(2H)isoquinolones acting as dienophiles. DA rea...
OBJECTIVES We investigated the effects of erythropoietin (EPO) on neovascularization and cardiac function after myocardial infarction (MI). BACKGROUND Erythropoietin exerts antiapoptotic effects and mobilizes endothelial progenitor cells (EPCs). METHODS We intravenously administered EPO (1,000 IU/kg) immediately [EPO(0) group], 6 h [EPO(6h) group], or 1 week [EPO(1wk) group] after the perma...
DNA encoding the coat protein (P3) of a Scottish isolate of potato leafroll virus (PLRV) was inserted into the genome of Autographa californica nucleopolyhedrovirus (AcNPV) such that the coat protein was expressed either in an unmodified form or with the addition of the amino acid sequence MHHHHHHGDDDDKDAMG at the N terminus (P3-6H). Insect cells infected with these recombinant baculoviruses ac...
The recovery of epididymal spermatozoa, their cryopreservation and posterior use on IVP of bovine embryos, has become an important tool to store genetic material from animals that have died unexpectedly or that have acquired reproductive inability. The present study aimed to evaluate the viability of spermatozoa from epididymides after their incubation on IVF medium supplemented or not with hep...
Three series of 3-(2-aminoheterocycle)-4-benzyloxyphenylbenzamide derivatives, 2-aminooxazoles, 2-aminothiazoles, and 2-amino-6H-1,3,4-thiadizines were designed, synthesized and evaluated as β-secretase (BACE-1) inhibitors. Preliminary structure-activity relationships revealed that the existence of a 2-amino-6H-1,3,4-thiadizine moiety and α-naphthyl group were favorable for BACE-1 inhibition. A...
Scanning tunneling microscopy (STM) was used to study the C60 adsorption on the Si rich (3x3) and C rich (43x43) surface of 6H-SiC(0001). At room temperature, triangular or hexagonal islands commensurating to the substrate structure at submonlayer coverages were observed. One of the interesting observations was the nucleation of the second layer of the C60 molecule^ even at submonlayer coverage...
Current advancement in electronic devices is so rapid that silicon, the semiconductor material most widely used today, needs to be replaced in some of the fields. Silicon carbide (SiC) is a wide band gap semiconductor satisfying requirements to replace silicon in devices operating at high power and high frequency at elevated temperature, and in harsh environments. Hexagonal polytypes of SiC, su...
Self-organization in porous 6H–SiC" (2000). Faculty Publications from the Department of Electrical and Computer Engineering. 7.
We report the influence of static mechanical deformation on zero-field spin splitting silicon vacancies in carbide at room temperature. use AlN/6H-SiC heterostructures deformed by growth conditions and monitor stress distribution as a function distance from heterointerface with spatially resolved confocal Raman spectroscopy. The V1/V3 V2 centers 6H-SiC, measured optically detected magnetic reso...
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