Elevated plasma levels of cytokines such as endothelin-1 (ET-1) have been shown to be associated with sickle cell disease (SCD). However, the role of ET-1 in the pathophysiology of SCD is not entirely clear. I now show that treatment of SAD mice, a transgenic mouse model of SCD, with BQ-788 (0.33 mg.kg(-1).day(-1) intraperitoneally for 14 days), an ET-1 receptor B (ET(B)) antagonist, induced a ...

OBJECTIVE To analyze the sequence difference between human A, B, and O alleles and establish the method of ABO genotyping by PCR direct sequencing. METHODS PCR-direct sequencing technique was used to analyze two regions of cDNA from A transferase gene, 233-433 and 660-788. RESULTS Two nucleotide substitutions at 258th and 297th were found in 233-433 region, and a nucleotide substitution at ...

In the present study, endothelin (ET) agonists and receptor selective antagonists were used to characterize ET receptors mediating constriction in guinea pig mesenteric veins (250-300 micrometers diameter) in vitro. The contribution of ET-evoked vasodilator release to venous tone was also explored. Computer-assisted video microscopy was used to monitor vein diameter. Endothelin-1 (ET-1), endoth...

This article aims at discussing the struggle of one Umayyads’ descendants who was able to escape from Abbasid army city Damascus (Syria) Andalusia (Al-Andalus). He managed re-establish power Umayyads in after collapse their Damascus, due attack. A qualitative method with library research-based used conducting this study, data were analyzed by using descriptive approach, technical analysis, and ...

CoRReCtioN 788 RNA Biology Volume 11 issue 6 CoRReCtioN Under the section " The Institute for Biology–Carl's New Home, " the artist who created " Darwin's Playground " was incorrectly identified. The artist's name is Tony Tasset, not Tony Tyson.

The aim of our study was to investigate mechanism of action of endothelins 1, 2 and 3 on spontaneous activity, tone and intraluminal pressure of human ureter. Both longitudinal tension and intraluminal pressure were recorded from the isolated segments of proximal human ureter. Endothelins 1, 2 and 3 (5.35x10(-11) M - 5.05x10(-8) M) produced concentration-dependent tonic contraction and sustaine...

0198-9715/$ see front matter 2012 Elsevier Ltd. A http://dx.doi.org/10.1016/j.compenvurbsys.2012.06.00 ⇑ Corresponding author. Tel.: +44 788 983 1988. E-mail addresses: [email protected] (A. Bolbol), ta [email protected] (I. Tsapakis), [email protected] 1 Tel.: +44 781 56

Nicolaidis C, Curry MA, Ulrich Y, et al. Could we have known? A qualitative analysis of data from women who survived an attempted homicide by an intimate partner. J Gen Intern Med 2003;18:788–94. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....