Zhuang, Daming, Alice-Corina Ceacareanu, Bogdan Ceacareanu, and Aviv Hassid. Essential role of protein kinase G and decreased cytoplasmic Ca levels in NO-induced inhibition of rat aortic smooth muscle cell motility. Am J Physiol Heart Circ Physiol 288: H1859–H1866, 2005. First published December 2, 2004; doi: 10.1152/ajpheart.01031.2004.—Hyperinsulinemia is a major risk factor for the developme...

Hyperinsulinemia is a major risk factor for the development of vascular disease. We have reported that insulin increases the motility of vascular smooth muscle cells via a hydrogen peroxide-mediated mechanism and that nitric oxide (NO) attenuates insulin-induced motility via a cGMP-mediated mechanism. Events downstream of cGMP elevation have not yet been investigated. The aim of our study was t...

This split-arch clinical study was performed to compare the effects of using 10% carbamide peroxide bleaching agent for one hour twice a day with its use for 8 hours/night on tooth color change, color stability and sensitivity. Method: Bleaching trays, with reservoirs for the six maxillary anterior teeth, were fabricated for 12 volunteers. The trays were cut into two halves between the left and...

We have investigated the effect of the soybean isoflavone genistein on 8-hydroxy-2'-deoxyguanosine (8-OHdG) formation in calf thymus DNA exposed to either UV irradiation or the Fenton reaction system. Under the conditions used we observed that UV light and the Fenton reaction significantly increase 8-OHdG formation in DNA. Co-incubation with genistein inhibits the formation of 8-OHdG induced by...

BACKGROUND Topical treatment of acne vulgaris on the back is challenging largely due to the extensive broad surface with difficult to reach areas. A "leave-on" foam is suited for application to the trunk due to ease of application and spreadability. Prior to this trial, no data on Propionibacterium acnes (P. acnes) reduction on the back has existed for any benzoyl peroxide (BP) formulations or ...

The peroxydatic activity of haemoglobin in the presence of hydrogen peroxide catalyses the oxidation of TMB to a coloured product. Haemoglobin peroxidase has been termed a 'pseudoperoxidase'7 because, unlike true peroxidases which exhibit specificity for phenols, erythrocytes contain a peroxidase (erythrocyte glutathione peroxidase) specific for oxidation of reduced glutathione. This causes the...

A sequential injection analysis (SIA) system with spectrophotometric detection was developed as an alternative method for estimating the concentration of lipid hydroperoxides, which are the primary products of the lipid peroxidation process. The lipid hydroperoxide quantification was based on a ferric thiocyanate method. Benzoyl peroxide was used to produce a standard calibration curve for the ...

We hypothesized that AA-2414, a novel thromboxane receptor blocker with antioxidant properties, would inhibit peroxide-induced vasoconstriction in the isolated perfused human placental cotyledon. In study 1, placental cotyledons (n = 5) were perfused serially for 20- min intervals with control KrebsRinger-bicarbonate (KRB) buffer, t-butyl hydroperoxide (Px; 100 microM), KRB buffer, and KRB buff...

The innate immune response to bacterial infections includes neutrophil chemotaxis and activation, but regulation of inflammation is less well understood. Formyl peptides, byproducts of bacterial metabolism as well as mitochondrial protein biosynthesis, induce neutrophil chemotaxis, the generation of reactive oxygen intermediates (ROI), and the production of the neutrophil chemoattractant, IL-8....