Pulmonary adenocarcinoma with high-risk pathological factors are known to be associated poor prognosis in early-stage non-small-cell lung cancer (NSCLC). Aumolertinib is a third-generation EGFR-TKI that has efficacy EGFR sensitive and resistant NSCLC. The of aumolertinib as adjuvant therapy resected stage I–III NSCLC remains unknown. Patients underwent completely pathologic micropapillary/solid...

Gliomas are the most common and aggressive primary tumors in adults. The current approaches, such as histological classification and molecular genetics, have limitation in prediction of individual therapeutic outcomes due to heterogeneity within the tumor groups. Recent studies have proposed several gene signatures to predict glioma's prognosis. However, most of the gene expression profiling st...

The blood-testis barrier (BTB) prevents the entry of many drugs into seminiferous tubules, which can be beneficial for therapy not intended for the testis but may decrease drug efficacy for medications requiring entry to the testis. Previous data have shown that some of the transporters in the multidrug resistance-associated protein (MRP) family (ABCC) are expressed in the testis. By determinin...

We invent a new science which is better than physics. It is even better than chocolate. It is not illegal, immoral, or fattening. However, thinking about it too hard does tend to give you a headache. On the other hand, thinking about it even harder makes your brain numb. <-------------------------------------150mm--------------------------------------> WARNING: Do not read this paper before ope...

Nicotine is an addictive alkaloid in cigarette smoke and is responsible for tobacco dependence. It is important to consider the bloodto-liver transport of nicotine to understand the nicotine elimination from the body because most of the nicotine is converted to inactive metabolites by cytochrome P450 localized in the endoplasmic reticulum of the hepatocytes. In this study, the blood-to-liver tr...

Nicotine is an addictive alkaloid in cigarette smoke and is responsible for tobacco dependence. It is important to consider the bloodto-liver transport of nicotine to understand the nicotine elimination from the body because most of the nicotine is converted to inactive metabolites by cytochrome P450 localized in the endoplasmic reticulum of the hepatocytes. In this study, the blood-to-liver tr...