1. In the present study, we have pharmacologically characterized two novel mixed endothelin ETA/ETB receptor antagonists, namely BQ-928 and BQ-238, in ETA and ETB preparations, the rabbit carotid artery (RbCA) and the rabbit pulmonary artery (RbPA), respectively. These two antagonists were compared to established ETA (BQ-123 and BMS 182874), ETB (BQ-788) and mixed ETA/ETB (SB 209670) receptor a...

INTRODUCTION ............................................................................................... 914 I. A TYPOLOGY OF DYSFUNCTION .......................................................... 916 A. Constitutional Dysfunction .......................................................... 916 B. Political Dysfunction ................................................................... 919 C....

Primordial germ cells (PGCs) form at the posterior pole of the Drosophila embryo, and then migrate to their final destination in the gonad where they will produce eggs or sperm. Studies of the different stages in this process, including assembly of germ plasm in the oocyte during oogenesis, specification of a subset of syncytial embryonic nuclei as PGCs, and migration, have been informed by gen...

The presence of low-copy-number regulators and switch-like signal propagation in regulatory networks are expected to increase noise in cellular processes. We developed a noise amplifier that detects fluctuations in the level of low-abundance mRNAs in yeast. The observed fluctuations are not due to the low number of molecules expressed from a gene per se but originate in the random, rare events ...

In recent years odds ratios have become widely used in medical reports—almost certainly some will appear in today’s BMJ. There are three reasons for this. Firstly, they provide an estimate (with confidence interval) for the relationship between two binary (“yes or no”) variables. Secondly, they enable us to examine the effects of other variables on that relationship, using logistic regression. ...

The prevalence of prices ending in 99 cents is explained as the result of rational consumers rounding prices up. Monopolists are shown to be harmed by this practice whereas consumers may gain. The model is compared with two other models: Basu’s (1997) model and one which assumes consumers round prices down. Corresponding author: Nigel W. Duck University of Bristol E-mail: [email protected] Te...

BACKGROUND Staurosporine is a therapeutic agent that inhibits tumor cell growth by inducing cell death via intrinsic apoptotic pathways. Our previous studies in clinical settings have suggested that certain subpopulations of patients with acute myeloid leukemia (AML) had poor response to chemotherapy. MATERIALS AND METHODS The effect of staurosporine on apoptosis and cell cycle distribution i...

The retinoblastoma tumor-suppressor gene, RB, has been implicated in tumor suppression, in regulation of the cell cycle, and in mediating cell differentiation. RB is necessary for hematopoiesis in mice, and aberrant RB-expression is associated with the progress and prognosis of leukemia. We have used antisense oligonucleotides, established clones stably expressing an antisense RB construct, and...