An observation by Duggleby [Biochem. J. (1979) 181, 255-256] that estimates of kinetic parameters by the jack-knife technique [Cornish-Bowden & Wong (1978) Biochem. J. 175, 969--976] are sometimes outside the range of estimates from which they are calculated has been examined. No significant correlation has been found between the occurrence of this behaviour and the actual quality of the estima...

We used two established neutropenic murine models of pulmonary aspergillosis and mucormycosis to explore the association between the posaconazole area under the concentration-time curve (AUC)-to-MIC ratio (AUC/MIC) and treatment outcome. Posaconazole serum pharmacokinetics were verified in infected mice to ensure that the studied doses reflected human exposures with the oral suspension, delayed...

MicroRNAs (miRNAs) are important regulators of gene expression and have been implicated in immunity inflammation. Chronic skin inflammation psoriasis is maintained by inflammatory circuits involving infiltrating immune cells keratinocytes. Recently we identified microRNA(miR)-149 to be suppressed keratinocytes showed that it acts as a link between IFN-g the TWEAK pathways. To further explore ro...

تعد نقابة الاشراف الطالبيين احدى مؤسسات الدولة الادارية في العربية الاسلامية ووظيفتها الأساسية هي حفظ أنساب الهاشمين من العلويين والعباسيين أنْ تكون مِدعاةَ الأخرين والعناية شؤونهم الخاصة والعامة.
 وصارت كلمة الأشراف تنسب إلى بيت النبِّي (صلى الله عليه واله وسلم) نسل الحسن والحسين عليهم السلام، وهي وظيفة شريفة ومرتبة نفيسة موضوعها التحدّث على اولاد عليّ بن أبي طالب (عليهم السلام ) فاطمة بنت رسول ...

Tyrer P, Thompson S, Schmidt U, et al. Randomized controlled trial of a brief cognitive behaviour therapy versus treatment as usual in recurrent deliberate self-harm: the POPMACT study. Psychol Med 2003;33:969–76; and Byford S, Knapp M, Greenshields J, et al. Cost-effectiveness of brief cognitive behaviour therapy versus treatment as usual in recurrent deliberate self-harm: a decision-making ap...

3. Hotelling H. Book review: the triumph of mediocrity in business. Journal of American Statistical Association 1933; 28:463–465. 4. Oldham PD. A note on the analysis of repeated measurements of the same subjects. Journal of Chronic Diseases 1962; 15:969–977. 5. Galton F. Regression toward mediocrity in hereditary stature. Journal of Anthropological Institute of Great Britain and Ireland 1886; ...

H. Piperidine Analogues of Phenyltropanes 967 III. Cocaine Analogues 969 A. Stereoisomers of Cocaine 970 B. Phenyl Ring Substituted Cocaines 970 C. 2â-Substituted Cocaines 973 1. 2â-Substituted Cocaines 973 2. 2â-Substituted 4′-Iodococaines 977 D. N-Modified Cocaines 978 E. 3â-Carbamoyl Analogues of Cocaine 981 F. 3â-Alkylphenyltropanes 982 G. 6/7-Substituted Cocaine and Pseudococaine 982 H. 6-...

. Burkett EL, Hershberger RE. Clinical and genetic issues in familial dilated cardiomyopathy. J Am Coll Cardiol 2005;45:969–81. . Kühl U, Pauschinger M, Noutsias M, et al. High prevalence of viral genomes and multiple viral infections in the myocardium of adults with “idiopathic” left ventricular dysfunction. Circulation 2005;111:887–93. . Poller W, Kühl U, Tschoepe C, et al. Genome–environment...