BACKGROUND Cobalamin (Cbl) deficiency has been associated with various neuropsychiatric symptoms of different severities. While some studies dedicated in structural neuroimaging credibly address negative impact of low Cbl status, functional imaging reports are limited. We herein retrospectively review the correlation of Tc-99 m ethyl cysteinate dimer single-photon emission computed tomography (...

OBJECTIVES Improved brain uptake ratio (IBUR), employing (99m)Tc-ethyl cysteinate dimer ((99m)Tc-ECD), is an automatic non-invasive method for quantitatively measuring regional cerebral blood flow (rCBF). This method was developed by the reconstruction of the theory and linear regression equation, based on rCBF measurement by H2 (15)O positron emission tomography. Clarification of differences i...

Conventional liposomes normally shows frequent uptake by reticuloendothelial system(RES). To reduce the RES uptake and to prolong the biological half life researchers aimed to prepare sterically stabilized liposomes containing charged or neutral particles as surface modifier for targeting various organs for therapeutic or diagnostic purposes. Film method followed by ultracentrifugation and soni...

A 7-year-old boy developed mutism after surgery for cerebellar medulloblastoma. Postoperative magnetic resonance imaging (MRI) showed atrophy of the cerebellar vermis and both cerebellar hemispheres, predominantly on the right side. Single photon emission computed tomography (SPECT) with technetium-99m-ethyl cysteinate dimer (Tc-99m ECD) revealed decreased cerebral blood flow (CBF) in the bilat...

OBJECTIVE The purpose of this study was to objectively assess the efficacy of superficial temporal artery to middle cerebral artery (STA-MCA) bypass surgery using Technetium (Tc)-99m-ethyl cysteinate dimer (ECD) single photon emission computed tomography (SPECT) in patients who underwent STA-MCA bypass surgery. MATERIALS AND METHODS Brain perfusion SPECT images obtained at baseline and after ...

OBJECTIVE The early diagnosis and treatment of cognitive impairment in cirrhotic patients is needed to improve the patients' daily living. In this study, alterations of regional cerebral blood flow (rCBF) were evaluated in cirrhotic patients using statistical parametric mapping (SPM). The relationships between rCBF and neuropsychological test, severity of disease and biochemical data were also ...

Introduction Functional neuroimaging techniques used to study narcolepsy include single-photon emission computed tomography (SPECT), positron emission tomography (PET), and functional magnetic resonance imaging (fMRI). SPECT shows the distribution of radioactive isotopes, the decay of which is associated with the emission of detectable single gamma photons. Examples of SPECT isotopes are techne...

With the use of perfusion tracers, in vivo examination of the regional cerebral blood flow in cats can be performed with single photon emission computed tomography (SPECT). Reliable perfusion data of normal, healthy cats are necessary for future clinical studies or other research use. Therefore, this dataset of the regional perfusion pattern of the normal feline brain was created. Twelve cats w...

The aim of this SPECT study was to investigate the effects of donepezil on regional cerebral blood flow (rCBF) in patients with mild to moderate Alzheimer’s disease (AD) using statistical parametric mapping. Methods: rCBF was noninvasively measured using 99mTc-ethyl cysteinate dimer in 35 AD patients with a Mini-Mental State Examination score . 16 on initial evaluation. Baseline and follow-up S...