Chronic fatigue syndrome (CFS) is a severely disabling illness of uncertain aetiology. It is characterized by a chronic, sustained or fluctuating sense of debilitating fatigue without any other known underlying medical conditions. It is also associated with both somatic and neuropsychological symptoms. Both physical and laboratory findings are usually unremarkable. Regional cerebral blood flow ...

in recent years, several radiopharmaceuticals have been developed for imaging regional cerebral blood flow (rcbf) such as 75se labelled pipse and mose, ²º¹ti labelled ddc and 99mtc labelled hmpao. hmpao with two asymmetric carbon atoms (at the 3 and 9 positions), produces d,1 and meso isomers, only one of which is retained in the brain. rapid intracellular conversion of 99mtc-d,1-hmpao to hydro...

BACKGROUND Restenosis after percutaneous coronary intervention (PCI) is a matter that still remains to be resolved. Herein, the inhibitory effect of locally delivered 99mTc-HMPAO (hexamethyl propylene amine oxime) on neointimal hyperplasia after coronary stenting was examined in a pocine model, and its safety and efficacy observed in patients with coronary stent restenosis. METHODS After a st...

AIM The aim of this study was to assess the role of labelled leukocyte scintigraphy in the diagnosis and monitorization of response to therapy of patients with active bronchiectasis. MATERIAL AND METHODS Twenty patients underwent (99m)Technetium hexamethylpropyleneamine oxime ((99m)Tc-HMPAO) labelled white blood cell (WBC) scintigraphy. A second scintigraphy was performed in 13 patients at 10...

UNLABELLED The aim of this study was to evaluate the diagnostic value, in suspected infectious prostheses, of (99m)Tc-labeled hexamethylpropyleneamine oxime ((99m)Tc-HMPAO) leukocyte scintigraphy interpreted with the addition of a semiquantitative analysis. METHODS By means of a retrospective review, we included a group of 78 consecutive patients with suspected hip or knee prosthesis infectio...

To assess semantic memory and frontal executive function, two patients underwent neuropsychological testing during transient global amnesia (TGA) and after an interval of 6-8 weeks. In spite of a profound deficit in anterograde verbal and non-verbal memory, semantic memory was normal, as judged by category fluency measures, picture naming, and picture-word and picture-picture matching, and read...

In recent years, several radiopharmaceuticals have been developed for imaging regional cerebral blood flow (rCBF) such as 75Se labelled PIPSE and MOSE, ²º¹TI labelled DDC and 99mTc labelled HMPAO. HMPAO with two asymmetric carbon atoms (At the 3 and 9 positions), produces d,1 and meso isomers, only one of which is retained in the brain. Rapid intracellular conversion of 99mTc-d,1-HMPAO to...

Twenty-one inpatients (15 males/6 females) with an average age of 23.7 years, who had been diagnosed with FEP according to DSM-IV-TR (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition,Text Revision) criteria, were evaluated using the Positive and Negative Syndrome Scale (PANSS). SPECT was acquired after injection of Tc-HMPAO (Tc-hexamethylpropyleneamine oxime), before drug t...

Scintigraphy with autologous granulocytes labelled by technetium-99m hexamethyl, propylene amine oxime (99mTc-HMPAO) was performed in 103 Crohn's disease patients and 52 healthy controls. In 31 patients endoscopic and histologic activity was compared with scan activity index. In the 98 patients with a positive scan, the extent of Crohn's disease, assessed by scintigraphy, was compared with that...

Background The ability to follow the distribution and migration of biologically active cells in human is essential for the development of cell-based therapies and diagnostics. Nuclear medicine imaging is widely applied in clinic as an attractive technique for in vivo WBC and stem cell tracking. The aim of this study was to evaluate prosthesis infection of a 51 years old man with previous histo...