The optimal fractionation schedule for radiotherapy of head and neck cancer has been controversial. The objective of this randomized trial was to test the efficacy of hyperfractionation vs. standard fractionation. Patients with squamous cell carcinoma of head and neck organs were randomly assigned to receive radiotherapy delivered with A) standard fractionation at 2 Gy/fraction/day, 5 days...

BACKGROUND Conventional cardiac pacemakers are still often regarded as a contraindication to magnetic resonance imaging (MRI). We conducted this study to support the hypothesis that it is safe to scan patients with cardiac pacemakers in a 1.5 Tesla MRI, if close supervision and monitoring as well as adequate pre- and postscan programming is provided. METHODS We followed up 356 patients (age 6...

In this assignment we studied Google Local’s Maps and Restaurants data. The goal was to extract restaurants’ information from the dataset and to study how restaurants perform based on different features offered by the dataset. We studied three main features and how they affect a restaurant to stay in business; one was related to the geographical grouping of the restaurants, the other was how us...

Family Planning Perspectives pared with 63% of those among Hispanic women and 54% of those among white and other non-Hispanic women.2 The greater prevalence of unplanned pregnancy among low-income women and among black or Hispanic women reflects their lower levels of contraceptive use3 and higher likelihood of contraceptive failure.4 However, it is not clear whether racial and ethnic difference...

BACKGROUND Emerging molecular, animal model and epidemiologic evidence suggests that Shiga-toxigenic Escherichia coli O157:H7 (STEC O157) isolates vary in their capacity to cause human infection and disease. The translocated intimin receptor (tir) and intimin (eae) are virulence factors and bacterial receptor-ligand proteins responsible for tight STEC O157 adherence to intestinal epithelial cel...

Th e primary debate among scholars who study the evolution of religion concerns whether religion is an adaptation or a byproduct. Th e dominant position in the fi eld is that religious beliefs and behaviors are a byproduct of cognitive processes and behaviors that evolved for other purposes. A smaller group of scholars maintain that religion is an adaptation for extending human cooperation and ...

In this paper we implement a collaborative filtering algorithm on the MovieLens dataset to predict movie ratings for the users. The original matrix, which contains the movie ratings on a 1-5 scale for the users, has many missing entries. Rank-K factorization is used to construct the filtering algorithm and alternating least squares is then performed on the two lower rank matrices in order to fi...

Bortezomib is a highly selective inhibitor of the 26S proteasome and has been approved for clinical use in the treatment of relapsing and refractory multiple myeloma and mantle cell lymphoma. Clinical trials are also underway to assess the role of bortezomib in several other human malignancies, including leukemia. However, the mechanism(s) by which bortezomib acts remain to be fully understood....