INTRODUCTION Concentrations of B-type natriuretic peptide (BNP) are recognised as a reliable marker of ventricular dysfunction in adults. In this study, plasma levels of BNP were determined in children with congenital heart disease (CHD) involving a left-to-right shunt, and were correlated with the shunt volume. METHODS Seventy-six children (38 boys/38 girls, mean age 22.4 months) with CHD (G...

background occult hepatitis b infected (obi) patients cannot eradicate hepatitis b virus (hbv)-dna from their liver and peripheral blood, completely. objectives the main aim of this study was to investigate the rate of hla-a2 expression on peripheral blood mononuclear cells (pbmcs) of patients with obi. materials and methods in this experimental study, intensity of hla-a2 was measured on the pb...

INTRODUCTION Determination of ABO and Rh blood group types are clinically important for various purposes including transfusion. There is a wide regional, racial, ethnic variability among these groups. We aim to determine the patterns in patients attending tertiary care center Western Nepal. MATERIAL AND METHODS This hospital-based cross-sectional study involved 600 visiting Universal College Me...

We analyzed the ability of a diverse set of mammalian secreted phospholipase A(2) (sPLA(2)) to release arachidonate for lipid mediator generation in two transfected cell lines. In human embryonic kidney 293 cells, the heparin-binding enzymes sPLA(2)-IIA, -IID, and -V promote stimulus-dependent arachidonic acid release and prostaglandin E(2) production in a manner dependent on the heparan sulfat...

Platelets express ABH antigens, which can adversely effect platelet transfusion recovery and survival in ABH-incompatible recipients. To date, there has been no large, comprehensive study comparing specific donor factors with ABH expression on platelet membranes and glycoconjugates. We studied ABH expression in 166 group A apheresis platelet donors by flow cytometry, Western blotting, and thin ...

Umbilical cord blood (UCB) is increasingly used as a source of hematopoietic progenitor cells to treat a variety of disorders. UCB transplant is associated with comparatively reduced incidence of graft-versus-host disease, robust graft versus leukemia effect, and relatively high incidence of opportunistic infections, three processes in which donor-derived T lymphocytes are known to be predomina...

We investigated a possible link between endometriosis and polymorphism of the progesterone receptor gene (PROGINS). The endometriosis group consisted of 54 patients with a diagnosis of endometriosis by laparoscopy, and the control group comprised 44 women without endometriosis. Genotypes for PROGINS polymorphisms (A1/A1, A1/A2 and A2/A2) were determined by polymerase chain reaction and analyzed...

Celery (Apium graveolens L.) is a plant that belongs to the Apiaceae family and widely used as medical for low blood pressure, heart tonic, prevent cardiovascular disease. This study aims obtain flavonoid compounds, identify, test antioxidant activity of compounds crude extracts from celery leaves. The research procedures consisted four steps, first which was preliminary test. second step invol...