Improvement in interaural phase difference (IPD) discrimination over 2 to 3 h was compared for two two-alternative forced-choice paradigms: A three-interval paradigm, in which the IPD was in interval two or three, and a paradigm with two intervals of four stimuli in which the IPD was in the second and fourth stimuli of one interval (AAAA vs ABAB). The difference in performance between the begin...

Human EMCs (extraskeletal myxoid chondrosarcomas) are soft tissue tumours characterized by specific chromosomal abnormalities. Recently, a proportion of EMCs were found to harbour a characteristic translocation, t(3;9)(q11-12;q22), involving the TFG (TRK-fused gene) at 3q11-12 and the TEC (translocated in extraskeletal chondrosarcoma) gene at 9q22. The present study used both in vitro and in vi...

BACKGROUND Phospholemman (PLM) is an important phosphorylation substrate for protein kinases A and C in the heart. Until now, the association between PLM phosphorylation status and L-type calcium channels (LTCCs) gating has not been fully understood. We investigated the kinetics of LTCCs in HEK 293T cells expressing phosphomimetic or nonphosphorylatable PLM mutants. METHODS The LTCCs gating w...

The correct removal of 5'-flap structures by Rad27 and Dna2 during Okazaki fragment maturation is crucial for the stable maintenance of genetic materials and cell viability. In this study, we identified RAD52, a key recombination protein, as a multicopy suppressor of dna2-K1080E, a lethal helicase-negative mutant allele of DNA2 in yeasts. In contrast, the overexpression of Rad51, which works co...

Science gateways have emerged as a concept for allowing large numbers of users in communities to easily access high-performance computing resources which previously required a steep learning curve to utilize. In order to reduce the complexity of managing access for these communities, which can often be large and dynamic, the concept of community accounts is being considered. This paper proposes...

CaS, SrS and BaS bsvm bean araporatad and the Tapor analyzed bgr aaaa apeotroaatrj. The following thanoehaalcal data «ara obtained: D^SjP-TTtf; Dl(CaS)-73.m.5; D;(3rS)-74.1±4.5j p;(BaS)-94.7±4.5i AH(dlJB.BaS)-113.9±5i ^H298nv(CaS)-U8.0±5; AH29eTlip(SrS)-U3.0±5; AH298Tap(BaS)-122.5±5; Dl(CaO)-84.A±6; lC(SxO)-92.2±6; Dl(BaO)=130.4±6; D*(SO)-123.5 kcal per sole. Thie technical docueentary report h...

Enteropathogenic Escherichia coli (EPEC) interferes with host cell signaling by injecting virulence effector proteins into enterocytes via a type III secretion system (T3SS). NleB1 is a novel T3SS glycosyltransferase effector from EPEC that transfers a single N-acetylglucosamine (GlcNAc) moiety in an N-glycosidic linkage to Arg(117) of the Fas-associated death domain protein (FADD). GlcNAcylati...

Binding of the cardiac hormone atrial natriuretic peptide (ANP) to transmembrane guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA), produces the intracellular second messenger cGMP in target cells. To delineate the critical role of an endocytic signal in intracellular sorting of the receptor, we have identified a FQQI (Phe(790), Gln(791), Gln(792), and Ile(793)) motif in the carboxyl-...

Recorded geoacoustic signals often contain noise and interference. Their appearance is caused by various reasons, e.g. of propagation environment heterogeneity, weather condition influence, human activity, etc. So, emission a persistent background that changes in intensity over time. This significantly distorts the pulse waveforms thus complicates analysis signal characteristics. The article pr...

How do infants' thoughts compare to the adults express with language? In particular, can infants entertain negative representations, such as not red or here? four experiments, we used pupillometry ask whether representations are possible without an external language. Eleven-month-olds were tested on their ability detect and represent abstract structure of sequences syllables, defined by relatio...