Collins, Colorado 80524, USA. Phone: [970] 498 2334, Fax: [970] 221 3124, Email: [email protected] The use of the wind tunnel as a building design tool has become much more commonplace in recent years. Its effective use requires close coordination between the architect, the structural engineer and the wind engineer, with the architect traditionally serving as project leader. Many structural ...

In every tunnel boring machine (TBM) tunneling project, there is an initial low production phase so-called the Learning Phase Period (LPP), in which low utilization is experienced and the operational parameters are adjusted to match the working conditions. LPP can be crucial in scheduling and evaluating the final project time and cost, especially for short tunnels for which it may constitute a ...

A proposal has been made to build a new tunnel under the Scheldt river near the centre of Antwerp in order to relieve traffic congestion on the ring road and in an existing tunnel. The new tunnel is expected to cost more than €1 billion, and tolls have been suggested to help finance construction and to manage demand. This paper conducts a preliminary cost-benefit analysis of a new tunnel and th...

T his research effort originated during the design of the Central Artery/Tunnel (CA/T) project in Boston. The Commonwealth of Massachusetts, in conjunction with the Federal Highway Administration (FHWA), is undertaking a $5 billion project to widen and depress the existing Central Artery (I-93) through downtown Boston and construct a third harbor tunnel (1-90) below Boston Harbor. During subseq...

successful application of a tbm in a project requires investigating both the ground conditions and the machine and backup system design features. prediction of the machine performance is very important as it has a big effect on the duration of the project and the costs. in this respect, both penetration rate and advance rate must be estimated. utilization factor, which depends on the type of op...

A major obstacle to the development of effective treatment of Alzheimer's disease (AD) is successfully delivery of drugs to the brain. We have previously identified a series of benzothiazole phosphonate compounds that block the interaction of amyloid-β peptide with amyloid-β binding alcohol dehydrogenase (ABAD). A selective and sensitive method for the presence of three new benzothiazole ABAD i...

Current strategies for the treatment of Alzheimer's disease (AD) involve tackling the formation or clearance of the amyloid-beta peptide (Aβ) and/or hyper-phosphorylated tau, or the support and stabilization of the remaining neuronal networks. However, as we gain a clearer idea of the large number of molecular mechanisms at work in this disease, it is becoming clearer that the treatment of AD s...

A usability study evaluating dynamic tunnel concepts has been completed under the Aviation Safety and Security Program, Synthetic Vision Systems Project. The usability study was conducted in the Visual Imaging Simulator for Transport Aircraft Systems (VISTAS) III simulator in the form of questionnaires and pilot-in-the-loop simulation sessions. Twelve commercial pilots participated in the study...