Synaptic plasticity is the capacity generated by experience to modify the neural function and, thereby, adapt our behaviour. Long-term plasticity of glutamatergic and GABAergic transmission occurs in a concerted manner, finely adjusting the excitatory-inhibitory (E/I) balance. Imbalances of E/I function are related to several neurological diseases including epilepsy. Several evidences have demo...

BACKGROUND In acquired heart disease, brain natriuretic peptide (BNP) and N-Terminal pro-brain natriuretic peptide (NT-proBNP) are increasingly used as diagnostic and prognostic markers. In adult congenital heart disease, the abnormal anatomy and physiology complicate assessment of cardiac function. We studied the clinical correlates of measurement of natriuretic peptides (NP) in adults with a ...

the liver is a multifactorial organ which is involved in a number of critical excretory, synthetic and metabolic functions. although the term 'liver function test' is commonly used, it is imprecise since many of the tests, such as transaminase, do not measure liver function. therefore, these tests should be referred to as 'liver enzyme tests', and 'liver function tests' should be the term used ...

Hypopituitarism is a multifaceted medical disorder with a complex aetiology Endocrinology remains a content heavy discipline and places great focus on understanding the transition from normal to the abnormal. Especially during the clerkship and clinical years, expectations are high regarding the understanding of the basic function of pituitary gland and clarity and reference to the function and...

Gynaecological endocrinology is concerned with the secretion of hormones by the ovary, the control of ovarian function by the pituitary and the manifestation of ovarian activity by the behaviour of the endometrium and the character and regularity of menstrual bleeding. It is necessary, therefore, to understand the physiology of ovarian hormone secretion, its control and manifestations, the natu...