Hundreds of distinct epilepsy-causing genes have been identified.1 The vitamin B6-dependent epilepsies are a heterogeneous group genetic disorders due to incomplete formation, transport, or inactivation pyridoxal 5′-phosphate (PLP).2 ALDH7A1 , PNPO ALPL ALDH4A1 and more recently PLPBP implicated.3 Characteristic presentation includes neonatal onset encephalopathy seizures refractory first-line ...

Multiple kernel learning (MKL) optimally combines the multiple channels of each sample to improve classification performance. However, existing MKL algorithms cannot effectively handle the situation where some channels are missing, which is common in practical applications. This paper proposes an absent MKL (AMKL) algorithm to address this issue. Different from existing approaches where missing...

The example of the ‘‘absent-minded driver’’ was introduced by Piccione and Rubinstein in the context of games and decision problems with imperfect recall. They claim that a ‘‘paradox’’ or ‘‘inconsistency’’ arises when the decision reached at the ‘‘planning stage’’ is compared with that at the ‘‘action stage.’’ Though the example is provocative and worth having, their analysis is questionable. A...

Patient presentation: An otherwise healthy 29-year-old white woman presented to our emergency department with leg pain and edema. She was well until 2 weeks before, when she developed lower back pain following a 3-hour flight. Her pain progressed despite treatment with ice packs, nonsteroidal anti-inflammatory drugs, and stretching, and it became so severe that she was unable to sit comfortably...