Purpose: To investigate the penetration enhancing effect of two polysorbates polyoxyethylene 20 (POE-20) and polyoxyethylene 80 (POE-80) on the in vitro percutaneous absorption of ascorbic acid (AA). Methods: For the permeation experiments, Franz diffusion cell covered with aluminum foil providing an effective diffusion area of 1.76 cm 2 and hairless rabbit skin were used. A range of concentrat...

Palmitoyl carnitine chloride (PCC) has been shown to be an effective enhancer of intestinal transport of hydrophilic molecules. The exact mechanism by which the epithelial barrier function is decreased is not clear. In an attempt to elucidate the mechanism of action of PCC, we studied the relationship among absorption enhancement, cell viability and tight junction protein localization in the hu...

Latar belakang: Kadar hemoglobin rendah menyebabkan anemia dalam kehamilan. Faktor yang mempengaruhi kadar adalah zat besi, vitamin C sebagai enhancer dan kalsium inhibitor besi. Tujuan penelitian ini untuk mengetahui pengaruh asupan kalsium, terhadap ibu hamil.Metode: Penelitian menggunakan pendekatan tinjauan sistematis dengan metode PRISMA. Pencarian literatur database elektronik yaitu SCOPU...

Food iron is absorbed by the intestinal mucosa from two separate pools of heme and nonheme iron. Heme iron, derived from hemoglobin and myoglobin, is well absorbed and relatively little affected by other foods eaten in the same meal. On the other hand, the absorption of nonheme iron, the major dietary pool, is greatly influenced by meal composition. Ascorbic acid is a powerful enhancer of nonhe...

In this study a 3D printed capsule designed to break from the physiological pressures in antropyloric region was evaluated for its ability deliver synthetic octapeptide octreotide beagle dogs when co-formulated with permeation enhancer sodium caprate. The pressure sensitive capsules were compared traditional enteric coated hard gelatin and tablets. Paracetamol, which is completely absorbed dogs...

topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. the new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. the adhesive capacity of hydroxypropyl methylcellulose (hpmc) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling tester. ...

the aim of this study was evaluation of phytochemical components, antioxidant activity, and antibacterial effects of basil (ocimum basilicum l.) essential oil (beo) in vitro. the lipid oxidation of the meat and antibacterial effects of beo were also evaluated in beef burger product. in this empirical study, essential oil of the basil was isolated by hydrodistillation. then, beo was analyzed by ...