BACKGROUND Antiretroviral therapy has reduced the incidence of adverse events and early mortality in HIV-infected persons. Despite these benefits, important comorbidities that increase with age (eg, diabetes, cardiovascular disease, cancer, liver disease, and neurocognitive impairment) are more prevalent in HIV-infected persons than in HIV-uninfected persons at every age, and geriatric syndrome...

1 Faculty member, Agricultural and Natural Resources Research Center of Yazd, Iran ABSTRACT. Seed aging is the main problem of seed storage. Changes of enzyme activity and reduction of seedling growth are consequence of seed deterioration. An experiment was conducted to evaluate the effects of accelerated aging on germination indexes and enzyme activity of barley seeds. Seeds were incubated in ...

Defects of mitochondrial DNA (mtDNA) maintenance have recently been associated with inherited neurodegenerative and muscle diseases and the aging process. Twinkle is a nuclear-encoded mtDNA helicase, dominant mutations of which cause adult-onset progressive external ophthalmoplegia (PEO) with multiple mtDNA deletions. We have generated transgenic mice expressing mouse Twinkle with PEO patient m...

OBJECTIVES Salthouse illustrated that among Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) participants, cognitive change accelerated following training. Our goal was to determine if this finding persists net of practice, training, and loss of training gains effects. METHODS We evaluated change over 5 years following cognitive training among older adults (N = 1,659, ag...

Cellular senescence is a phenomenon occurring when cells are no longer able to divide even after treatment with growth stimuli. Because senescent cells are typically associated with aging and age-related diseases, cellular senescence is hypothesized to contribute to the age-related decline in reproductive function. However, some data suggest that senescent cells may also be important for normal...

Facial aging is a multifactorial, three-dimensional (3D) process with anatomic, biochemical, and genetic correlates. Many exogenous and endogenous factors can signifi cantly impact the perceived age of an individual. Solar exposure [ 1– 3 ] , cigarette smoking [ 1, 2, 4, 5 ] , medications [ 1 ] , alcohol use [ 1 ] , body mass index [ 2 ] , and endocrinologic status [ 1, 6, 7 ] have all been imp...

Over the last hundred years, life expectancy in developed countries has increased because of healthier living habits and treatment chronic pathologies causing premature aging. Aging is an inexorable, time-dependent, multifactorial process characterized by a series progressive irreversible physiological changes associated with loss functional, psychological, social capabilities. Numerous factors...

Chronic medical conditions and/or their treatments may interact with aging to alter or even accelerate brain senescence. Adult onset cancer, for example, is a disease associated with advanced aging and emerging evidence suggests a profile of subtle but diffuse brain injury following cancer chemotherapy. Breast cancer is currently the primary model for studying these "chemobrain" effects. Given ...

Muscle wasting is a major cause of morbidity in the elderly. Ku80 is required for DNA double strand repair and is implicated in telomere maintenance. Complete loss-of-function leads to reduced post-natal growth and severe progeria in mice. We examined the role of Ku80 in age-related skeletal muscle atrophy. While complete loss of Ku80 leads to pronounced aging in muscle as expected, accompanied...