Multi-walled carbon nanotubes (MWCNTs) have been widely used in many fields and were reported to cause reversible testis damage in mice at high-dose. However the reproductive effects of low dose MWCNTs remained elusive. Herein, we used the mice spermatocyte cell line (GC-2spd) to assess the reproductive effects of MWCNTs. Size distribution, zeta potential, and intensity of MWCNTs were character...

Severe soil liquefaction due to a long duration earthquake with low acceleration occurred at Tokyo Bay area in the 2011 off the Pacific coast of Tohoku Earthquake. This phenomenon clearly shows that soil liquefaction is affected by properties of input waves. This paper describes effect of wave properties of earthquake on liquefaction using effective stress analysis with some earthquakes. Analyt...

This paper presents a method for uncertainty analysis of prognostics with a focus on electronics subject to random vibration. First we identify uncertainty sources and types: measurement uncertainty, parameter uncertainty, failure criteria uncertainty, and future usage uncertainty. Next, we present an approach to determine the uncertainty in a prognostic analysis. Our approach utilizes a sensit...

SUMMARY c The concept that creep response is the result of a transient approach to a minimum strain rate continuously modified by accumulating damage has been investigated using high precision creep data. It was considered that the accumulated creep strain might be some measure of internal damage and curves of log creep strain rate against creep strain are shown to exhibit linearity at higher s...

Goal of the work is to develop a methodology for researching possibility further exploitation drums boiler units thermal power plants after exhausting their park resource. Significance. During long-term operation TPP units, which under action high pressure, elevated temperature, repeatedly changing cyclic loads, influence corrosive-active working environment, water-steam mixture, stressed metal...

This paper presents the concept and architecture of a fatigue damage control system for mechanical structures. In contrast to the conventional cycle-based approach, fatigue damage is represented via non-linear differential equations with respect to time in the state-variable setting. This damage model is compatible with the dynamic model of the plant, i.e. the process under operation and contro...

Here we report that RNA interference against ATM inhibited p53 accumulation in cells expressing oncogenic STAT5 and cooperated with Rb inactivation to suppress STAT5A-induced senescence. Knocking down ATM was also effective to bypass E2F1-induced senescence and in combination with Rb inactivation, inhibited RasV12-induced senescence. Cells that senesced in response to ca-STAT5A or RasV12 accumu...

The objective of life extending control (LEC), also known as damage mitigating control, is to design a controller to achieve a good tradeoff between structural durability and dynamic performance in a system. In this paper, continuum fatigue damage theory for a boiler system is discussed. To reduce the accumulated damage, a variance constrained model predictive control (VCMPC) problem is develop...

Background: Doxorubicin (DOX), a widely used antineoplastic compound, is associated with testicular damage and infertility. In this study, we intended to determine the possible preventive effects of simvastatin (SIM), a lipid lowering agent with antioxidant and anti-inflammatory activities, on testicular morphometric-stereological changes due to DOX treatment in mice. Materials and Methods: Mal...