Skin and oral mucosa substitutes are a therapeutic option for closing hard-to-heal skin and oral wounds. Our aim was to develop bi-layered skin and gingiva substitutes, from 3 mm diameter biopsies, cultured under identical conditions, which are compliant with current European regulations for advanced therapy medicinal products. We present in vitro mode of action methods to (i) determine viabili...

Clinical studies of component (“acellular”) pertussis vaccines have been undertaken in recent years, and several acellular vaccines have been used in Japan for 10 years. The Committee has reviewed these trials and related data and herein provides its assessment regarding the current status of the acellular vaccines and their possible use in the United States. The pertussis vaccines in current u...

Clinical studies of component (“acellular”) pertussis vaccines have been undertaken in recent years, and several acellular vaccines have been used in Japan for 10 years. The Committee has reviewed these trials and related data and herein provides its assessment regarding the current status of the acellular vaccines and their possible use in the United States. The pertussis vaccines in current u...

BACKGROUND The recent increase in popularity of acellular dermal matrix assistance in immediate expander/implant breast reconstruction has led to variety of viewpoints. Many studies are published indicating an increase in complications with the use of acellular dermal matrix, while others indicate there is no increase in complications. METHODS This meta-analysis utilizes information from avai...

In the present study, biocompatibility of native, acellular, 1,4-butanediol diglycidylether and 1-ethyl-3-(3-dimethyl aminopropyl carbodiimide (EDC) cross-linked acellular aortic grafts was evaluated following subcutaneous implantation in guinea pigs. Biocompatibility was evaluated based on macroscopic, histopathological observations and immune responses elicited by the implanted grafts. Result...

OBJECTIVE To provide a review of pertussis vaccines, including information on efficacy, adverse reactions, and antibody production following administration of both whole-cell and acellular pertussis vaccines. DATA SOURCES A MEDLINE search and extensive review of journals was conducted to identify the information for this review. DATA EXTRACTION Pertinent studies reporting experience with pe...

Magnetic attachments have been applied for various prostheses. In this report, a fixed partial denture (FPD) to which a detachable gingiva was connected by magnetic attachment was fabricated to support esthetic recovery of the alveolar bone defect and the maxillary anterior missing teeth. Missing teeth, accompanied with an alveolar bone defect, are generally recovered with a removable denture o...

One of the most common mucoginigival problems are gingival recession with decreased width of attached gingiva and shallow vestibule. Many techniques have been employed till date to increase the width of attached gingiva and for root coverage. But in all these techniques multiple surgeries had to be performed to achieve predictable results. In such procedures, firstly the width of attached gingi...

Value, chroma, and hue of gingiva of 100 black and 100 white patients were measured clinically with Munsell color tabs under fluorescent light and under simulated daylight. The color of uniformly pigmented attached gingiva of both blacks and whites was described most often by a value between 5/ and 7/, a chroma of /4, and a range of hues from 2.5R to 7.5R when determined under fluorescent light...

HoDGE[1] reported the determination of lipids in human gingiva. FISHER et al.[2] investigated into the cholesterol contents in bovine and human gingiva. STERN et al.[3] observed the incorporation of sodium acetate-1-14C into cholesterol, palmitic acid and oleic acid in human gingiva. OTAKE et al.[4] also reported the incorporationof sodium acetate-1-14C into the lipid fractions in guinea pig gi...