Acetic acid induced colitis in rats was used to investigate the effects of malotilate, a drug which has been shown to inhibit 5-1ipoxygenase in human macrophages, the malotilate derivate ZY16268 and the flavenoid ZY16369 on the eicosanoid production and the colonic morphology in inflammatory bowel disease. Acetic acid produced an acute inflammatory response in the colon, associated with a marke...

Introduction: Ulcerative colitis is a chronic inflammation of the large intestine (colon). In patients with ulcerative colitis, ulcers and inflammation of the inner lining of the colon lead to symptoms such as abdominal pain, diarrhea, and rectal bleeding. Previous studies have shown that Matricaria recutita L. have a series of physiological effects for example spasmolytic, carminative, anti...

Reactive oxygen species has been implicated to contribute significantly to tissue injury associated with ulcerative colitis. Thus compounds with antioxidant properties could be potential therapeutic agents in this disease. Flavonoid compounds are known to possess antioxidative and antiinflammatory properties. Two derivatives of the flavonoid quercetin (Q), chloronaphthoquinone quercetin (CNC) a...

BACKGROUND Reactive oxygen species may mediate tissue injury in inflammatory bowel disease. Aminosalicylates have antioxidant activity and the antioxidants, superoxide dismutase and allopurinol, are of reported benefit in inflammatory bowel disease. AIM To develop a convenient technique for testing the antioxidant potential of standard and novel therapeutic agents for use in inflammatory bowe...

Objective(s) Matricaria aurea is found abundant in Iran and has large similarities in constituents especially essential oils, flavones and flavonoides as well as traditional uses to the main species; Matricaria recutita L. Anti-inflammatory, antioxidant and spasmolytic properties of the main species suggest that this plant may have beneficial effects on inflammatory bowel diseases so the prese...

BACKGROUND The aim of this study was to investigate the mechanisms underlying the therapeutic effect of Uygur medicine KJA on UC in a rat model. METHODS UC was induced in Wistar rats by application of 2, 4-dinitrochlorobenzene and acetic acid and were then treated with three different doses of KJA, and normal saline as control. After treatment for 20 days, the gene expression profile of colon...

Ulcerative colitis (UC) is a wide-reaching health problem with unknown etiology and its high mortality rates. Conventional therapy for onset treatment of active UC includes immunomodulators, corticosteroids, purine analogues, antibiotics and 5-aminosalicylic acid. Unfortunately, after giving long term treatment to the patients associated with UC, these drugs are found to have undue side effects...

To evaluate the effect of ethanolic extract of leaves of Moringa olifera Lam. on acetic acid induced colitis in albino rats ethanolic extract of Moringa olifera was prepared by percolation method. Acute toxicity test was done by using OECD guidelines. Albino rats were divided into four groups (n=5). Group A and B received 3% gum acacia. Group C and D received ethanolic extract of Moringa olifer...

Background. Anti-inflammatory and immunomodulatory activities have been reported for maprotiline, a strong norepinephrine reuptake inhibitor. In addition, some other antidepressant drugs have shown beneficial effects in experimental colitis. Methods. All the animals were divided into normal and depressed groups. In normal rats colitis was induced by instillation of 2 mL of 4% acetic acid and af...

OBJECTIVE The aim of this study was to determine the protective effects of Coriandrum sativum on acetic acid-inducedcolitis in rats. C. sativum (Coriander) has long been used in Iranian traditional medicine and its use as an anti-inflammatory agent is still common in some herbal formulations. MATERIALS AND METHODS Colitis was induced by intra-rectal administration of 2ml acetic acid 4% in fas...