A consensus exists that cholinesterase inhibitors (ChEIs) are efficacious for mild to moderate Alzheimer's Disease (AD). Unfortunately, the number of non-responders is large and the therapeutic effect is usually short-lasting. In experimental animals, ChEIs exert three main actions: inhibit cholinesterase (ChE), increase extracellular levels of brain acetylcholine (ACh), improve cognitive proce...

BACKGROUND Cholinesterase inhibitors are commonly used to treat dementia. These drugs enhance the effects of acetylcholine, and reports suggest they may precipitate bradycardia in some patients. We aimed to examine the association between use of cholinesterase inhibitors and hospitalization for bradycardia. METHODS AND FINDINGS We examined the health care records of more than 1.4 million olde...

In this study, the anti-cholinesterase activities of different extracts Achillea lycaonica, A. vermicularis and nobilis L. subsp. neilreichii (Kerner) Formanek species were examined then trace elements (Al, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Cd, Pb) plants analysed by ICP-MS. The pharmacokinetic properties phenolic compounds these previously analyzed us ADME-Tox (absorption, distribution, m...

CONTEXT Cholinesterase inhibitors are the primary treatment for the cognitive symptoms of Alzheimer disease (AD). Cholinergic dysfunction is also associated with neuropsychiatric and functional deficits, but results from randomized controlled trials of cholinesterase inhibitors are conflicting. OBJECTIVE To conduct a systematic review and meta-analysis to quantify the efficacy of cholinestera...

organophosphorous compounds have been employed as pesticides and chemical warfare nerve agents. toxicity of organophosphorous compounds is a result of excessive cholinergic stimulation through inhibition of acetyl cholinesterase. clinical manifestations include cholinergic syndromes, central nervous system and cardiovascular disorders. organophosphorous pesticide poisonings are common in develo...

background: the environmental degradation products of pesticides may enter drinking water and result in serious health problems. objective: to evaluate the occurrence of insecticides in drinking surface and ground water in dakahlyia governorate, northern egypt in 2011. methods: we studied blood samples collected from 36 consecutive patients diagnosed with pesticides poisoning and 36 tap drinkin...

Alzheimer disease is characterized by a loss of cholinergic neurons in the basal forebrain and a decrease in acetylcholine levels. Currently, cholinesterase inhibitors, drugs that act by inhibiting the enzyme responsible for the hydrolysis of acetylcholine, are the only therapy for the treatment of Alzheimer disease approved by the Food and Drug Administration. The cholinesterase inhibitors hav...

abstract pollution is a world problem with serious consequences. heavy metals are an important group of these contaminants and enter aquatic ecosystems from anthropogenic and natural sources and animal health and systems are affected. in this study, the effect of lead exposure (3 mg/l concentration, 30 days) on activity of tissue enzymes, including acetyl cholinesterase, alanine aminotransferas...