Skeletal muscle Akt activity stimulates muscle growth and imparts resistance to obesity, glucose intolerance and fatty liver disease. We recently found that ursolic acid increases skeletal muscle Akt activity and stimulates muscle growth in non-obese mice. Here, we tested the hypothesis that ursolic acid might increase skeletal muscle Akt activity in a mouse model of diet-induced obesity. We st...

enzymatic browning and formation of brown pigments are some of the most important problems in preparation of mushroom purees. in this study, the effect of some anti browning agents including sodium metabisulphite, ascorbic acid, and citric acid on the whiteness and foaming properties of mushroom purees was investigated. the results showed that soaking with acids and sodium metabisulphite signif...

In rodents, brown adipose tissue (BAT) plays an important role in producing heat to defend against the cold and can metabolize large amounts of dietary fatty acids (DFA). The role of BAT in DFA metabolism in humans is unknown. Here we show that mild cold stimulation (18 °C) results in a significantly greater fractional DFA extraction by BAT relative to skeletal muscle and white adipose tissue i...

The murine b locus encodes the tyrosinase related protein, TRP-1, a putative membrane-bound, copper-containing enzyme having about 40% amino acid identity with tyrosinase. The protein is essential for production of black rather than brown hair pigment. We show that skin of mutant brown mice contains the same amount of TRP-1 mRNA as wild type. On sequencing the coding region of the mutant mRNA w...

The melanocortin-1 receptor (MC1R) has been linked to intraspecific variation of melanin-based plumage color in several unrelated bird species. However, its involvement in interspecific variation has far less evidence. The Sulidae is a family in the Suliformes composed of 10 species of pelagic seabirds, distributed in 3 genera. There is significant variation in the amount and distribution of me...

tionen des lignins bei der Sulfatkochung. II. Modellversuche zur Spaltung von Arylalkyllatherbindingungen durch Alkali. Acta Chem. Scand. 16: 1713-29. 8. HANSON, K. R. AND .M. ZUCKER. 1963. The biosynthesis of chlorogenic acid and related conjugates of the hydroxycinnamic acids. J. Biol. Chem. 238: 1105-15. 9. HIGUCHr, T. 1957. Biochemical studies of lignin formation. II. Pihysiol. Plantarum 10...

Benzaldehyde and its metabolic intermediates were effectively degraded by the brown-rot basidiomycetes Tyromyces palustris and Gloeophyllum trabeum. The pathway of benzaldehyde degradation was elucidated by the identification of fungal metabolites produced upon the addition of benzaldehyde and its metabolic intermediates. The oxidation and reduction occurred simultaneously, forming benzyl alcoh...

In the Brown (Brown, 1955; Brown, Bulbrook & Greenwood, 1957) procedure for the determination of urinary oestrogens, losses may occur during the hydrolysis of the oestrogen conjugates and during the purification of the oestrogens thus formed. Losses during the latter stages were measured previously by adding free oestrogens to the hydrolysed urine. In the present study losses during acid and en...