نتایج جستجو برای: acid ceramidase
تعداد نتایج: 747667 فیلتر نتایج به سال:
We report here a novel fluorescent chemical probe which stains distinct neural stem/progenitor cells (NSPCs) by binding to acid ceramidase in mouse neurospheres. is distributed evenly or unevenly to the daughter cells during multiple mitoses enabling the live imaging of symmetric and asymmetric divisions of isolated NSPCs.
The epidermal barrier function is very important to maintain proper moisture in the human skin and protect inner body homeostasis. stratum corneum (SC) major player function. Interleukin (IL)-33 a tissue-derived cytokine, mainly expressed epithelial endothelial cells, activates Th2 lymphocytes, mast ILC2, eosinophils. We aimed study role of IL-33 steady state. Wild-type (WT), knockout (IL-33KO)...
The lysosomal acid ceramidase, an enzyme known to limit intracellular ceramide accumulation, has been reported to be defective in neurodegenerative disorders. We show here that rat hippocampal slices, preincubated with the acid ceramidase inhibitor (ACI) d-NMAPPD, exhibit increased N-methyl-D-aspartate (NMDA) receptor-mediated field excitatory postsynaptic potentials (fEPSPs) in CA1 synapses. T...
UNLABELLED Ceramide is an important signaling molecule that is typically generated via sphingomyelinase (SMase)-mediated sphingomyelin (SM) hydrolysis. Although diverse forms of renal injury elicit ceramide accumulation, the molecular determinants of this change and its contribution to tissue damage are poorly defined. The present study uses iron (Fe/hydroxyquinoline)-mediated injury of culture...
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