The urinary excretion rate is calculated based on short-term, defined time sample collections with a known sample mass, and this measurement can be used to remove the variability in urine concentrations due to urine dilution. Adjustment to the urinary excretion rate of hippuric acid was evaluated in 31 healthy volunteers (14 males and 17 females). Urine was collected as short-term or spot sampl...

Acid-base status and renal acid excretion were studied in the Dahl/Rapp salt-sensitive (S) rat and its genetically salt-resistant counterpart (R). S rats developed hypertension while on a very high salt diet (8%) and while on a more physiological salt diet (1%) and remained normotensive while on a very low salt diet (0.08%). Under the high salt diet, intracellular pH measured in freshly isolate...

Green tea polyphenol (Polyphenon) or tannic acid was administered orally to rats at a dose of 0.01–1.0 or 0.1– 1.0 g/kg for 23 days, and changes both in serum and hepatic lipid concentrations and in fecal steroid excretion were examined. The administration of 0.2–1.0 g/kg of Polyphenon caused a significant decrease in levels of serum HDLcholesterol, whereas tannic acid had no significant effect...

DUES, FEDERICO, GUADALUPE RAMOS, ESTHER AVELAR, AND MTGUEL LENNHOFF. Renal excretion of lactic acid in the dog. Am.J. Physiol. 216(l): 106-l 11. 1969.-The renal excretion of lactic acid was studied under different conditions in mongrel dogs, Previous reports that tubular reabsorption of lactic acid is rate limited were confirmed during experiments with rapid intravenous Na-lactate loading. Lact...

BACKGROUND The acid-ash hypothesis, the alkaline diet, and related products are marketed to the general public. Websites, lay literature, and direct mail marketing encourage people to measure their urine pH to assess their health status and their risk of osteoporosis.The objectives of this study were to determine whether 1) low urine pH, or 2) acid excretion in urine [sulfate + chloride + 1.8x ...

Rh B glycoprotein (Rhbg) is a member of the Rh glycoprotein family of ammonia transporters. In the current study, we examine Rhbg's role in basal and acidosis-stimulated acid-base homeostasis. Metabolic acidosis induced by HCl administration increased Rhbg expression in both the cortex and outer medulla. To test the functional significance of increased Rhbg expression, we used a Cre-loxP approa...

The demonstration by Harris, Ray, and Ward (1) of a correlation between the urinary excretion of ascorbic acid and the dietary intake has led to many investigations of ascorbic acid metabolism based on the technique suggested by these authors. Sendroy and Schultz (2) have given especial attention to some of the possible factors affecting tests based on urinary excretion values. A urinary excret...

1. Urinary excretion of dopa, catecholamines and their metabolites (vanillylmandelic acid, methoxycatecholamines, 3-methoxy-4-hydroxyphenylglycol and homovanillic acid) were studied in eighty patients with essential hypertension and in twenty-five healthy control subjects. 2. Increased urinary excretion of catecholamines, dopa and catecholamine metabolites was found in a proportion of cases. 3....

The usefulness of urinary glucaric acid determinations to measure enzyme induction by drugs was investigated by correlating its excretion rate with the daily drug regimen of 100 hospitalized patients. The urinary excretion of glucaric acid was higher in patients than in normal controls. Patients treated with enzyme inducers excreted more glucaric acid than patients not getting them, as well as ...

ences were greatest in 11 patients with unilateral renal arterial stenosis and were derived from reduced uric acid excretion per unit of glomerular filtration rate by the ischemic kidney. Six patients with unilateral stenosis underwent surgery with subsequent cure of hypertension. Another patient, who did not have impaired ipsilateral uric acid excretion, failed to respond to nephrectomy. Succe...