BACKGROUND In patients with multiple sclerosis (MS) the impact of urological symptoms on quality of life and daily activities is considerable. Yet, a substantial percentage of patients may not be urologically evaluated and thus fail to be treated concordantly. The 8-item Actionable questionnaire is a validated English screening tool for the detection of neurogenic bladder overactivity in MS. To...

Advances in genomic medicine have the potential to change the way we treat human disease, but translating these advances into reality for improving healthcare outcomes depends essentially on our ability to discover disease- and/or drug-associated clinically actionable genetic mutations. Integration and manipulation of diverse genomic data and comprehensive electronic health records (EHRs) on a ...

An efficient Actionable 3D Subspace Clustering based on Optimal Centroids from continuous valued data represented three dimensionally which is suitable for real world problems profitable stocks discovery , biologically significant protein residues etc. It achieves actionable patterns ,incorporation of domain knowledge which allows users to choose the preferred utility(profit/benefit) function, ...

This paper presents the advances in subgroup discovery and the ways to use subgroup discovery to generate actionable knowledge for decision support. Actionable knowledge is explicit symbolic knowledge, typically presented in the form of rules, that allow the decision maker to recognize some important relations and to perform an appropriate action, such as planning a population screening campaig...

People are often exposed to actionable food temptations (i.e., an immediate opportunity to consume, like when friends offer cookies) and nonactionable food temptations (i.e., no immediate consumption opportunity, like ads for chocolate). The results of three experiments suggest that prior exposure to nonactionable food temptations does not prevent the activation of an eating goal, given a subse...

Actionable knowledge has been qualitatively and intensively studied in the social sciences. Its marriage with data mining is only a recent story. On the one hand, data mining has been booming for a while and has attracted an increasing variety of increasing applications. On the other, it is a reality that the so-called knowledge discovered from data by following the classic frameworks often can...

BACKGROUND Angiosarcomas (AS) are rare in humans, but they are a deadly subtype of soft tissue sarcoma. Discovery sequencing in AS, especially the visceral form, is hampered by the rarity of cases. Most diagnostic material exists as archival formalin fixed, paraffin embedded tissue which serves as a poor source of high quality DNA for genome-wide sequencing. We approached this problem through c...

INTRODUCTION The promise of Clinical Decision Support (CDS) has always been to transform patient care and improve patient outcomes through the delivery of timely and appropriate recommendations that are patient specific and, more often than not, are appropriately actionable. However, the users of CDS-providers-are frequently bombarded with inappropriate and inapplicable CDS that often are not i...

PURPOSE We queried whether comprehensive genomic profiling using a next-generation sequencing-based assay could identify novel and unanticipated targets of therapy for patients with relapsed invasive lobular carcinoma (ILC). EXPERIMENTAL DESIGN DNA sequencing (Illumina HiSeq 2000) was conducted for 3,320 exons of 182 cancer-related genes and 37 introns of 14 genes frequently rearranged in can...