allogeneic hematopoietic stem cell transplantation (hsct) is the most effective therapy to prevent relapse in acute lymphocytic leukemia (all). this benefit is affected by non-relapse mortality (nrm) due to complications such as graft versus host disease (gvhd). a new approach in analyzing time-dependent covariates in competing risks is landmark analysis. so, the aim of this study is to evaluat...

Busulfan 16 mg/kg and cyclophosphamide 120 mg/kg were used as conditioning prior to allogeneic marrow transplantation in 50 adult patients with acute nonlymphocytic leukemia (ANLL), acute lymphocytic leukemia (ALL), and chronic myelogenous leukemia (CML). A standard risk group of 20 patients included those with acute leukemia in remission and CML in chronic phase. A high-risk group of 30 patien...

Background: This study was performed to evaluate the effects of probiotics on salivary flow rate and pH in children with Acute Lymphocytic Leukemia (ALL) during chemotherapy.   Methods: A randomized clinical trial was conducted on 11 children with ALL on induction and consolidation phases of chemotherapy. At the beginning, clinical examination of the oral mucosa and dental hygiene and intervie...

In an attempt to lay a sound foundation for understand ing the therapeutic effectiveness of glucocorticoids in the treatment of hematological cancers, we have studied glucocorticoid receptors and sensitivity to glucocorticoids in vitro in the malignant cells from 56 patients with leuke mia and lymphoma and in peripheral lymphocytes from normal donors. In contrast to several previous studies in ...

We employed three courses of intermediate dose Methotrexate (IDM) added onto a standard induction and maintenance program with the concept of both central nervous system (CNS) prophylaxis and simultaneous systemic intensification. Cranial radiation (RT) was not employed as CNS prophylaxis. Fifty of 52 patients (to age 18) achieved complete remission. Time on study now ranges from 22-68 months w...

Epidemiology and incidence Acute myeloid (AML) and acute lymphocytic leukemia (ALL) are rare diseases, accounting for approximately 1.3% and 0.4% of all new cancer cases in the US. While the overall incidence of leukemia has been stable since 1975 (13 new cases/ 100,000 in 1975 and 14 new cases/ 100,000 in 2012) [1], the rates for new AML and ALL cases have been rising on average by 2.2% and 0....

et al. Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia. Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease. a multicenter, international, phase 2 study of alvocidib for patients with fludarabine-refractory chron...

nitric oxide (no) is a molecule required for many physiological functions, produced from l-arginine by no synthases (nos). it is a free radical, producing many reactive intermediates that account for its bioactivity. sustained induction of the inducible form of nos (inos) in chronic inflammation may be mutagenic, through no-mediated dna damage or hindrance to dna repair, and thus potentially ca...