نتایج جستجو برای: acute myeloblastic leukemia
تعداد نتایج: 688174 فیلتر نتایج به سال:
Homogeneously staining regions (HSR) or double minute chromosomes (dmin) are autonomously replicating extra-chromosomal elements that are frequently associated with gene amplification in a variety of cancers. The diagnosis of leukemia patients was based on characterization of the leukemic cells obtained from bone marrow cytogenetics. This study report two cases, one with Acute Myeloblastic Leuk...
The terminal phase of most patients with Ph1-positive chronic granulocytic leukemia (i.e., blast crisis) resembles acute leukemia. The clinical and hematologic features of blast crisis in 73 patients with chronic granulocytic leukemia have been reviewed. Two major morphological subgroups, lymphoblastic and myeloblastic, were identified. The lymphoblastic group in general had more profound throm...
Transplantation of hematopoietic stem cells derived from bone marrow or peripheral blood has been used as a therapeutic procedure since the mid-seventies. In recent years, the number of transplants reported annually to the European Group for Blood and Marrow Transplantation (EBMT) Registry is approximately 23,500 including 38% of allogeneic and 62% of autologous procedures. In most developed co...
Acute promyelocytic leukemia (APL) is a unique form of acute myeloblastic leukemia, which manifests by DIVC, massive hemorrhage and hypofibrinogenemia and has a rapidly fatal outcome. Here we report a case of APL in a 38-year-old woman, who presented with an acute episode of severe menorrhagia for the first time and died due to hemorrhagic complications. The diagnosis of hematological disorders...
BACKGROUND The possibility of performing syngeneic hematopoietic stem cell transplantation is rare and there are concerns about the absence of a graft-versus-leukemia effect following such a strategy. We report the outcomes of a large series of adult patients who underwent syngeneic hematopoietic stem cell transplantation for acute myeloblastic leukemia or acute lymphoblastic leukemia. DESIGN...
Knowledge of the molecular mechanisms of leukemia has important implications for treatment, prognosis, and follow-up. In the case of acute promyelocytic leukemia (APL), one of the six main subtypes of acute myeloblastic leukemia (AML), the clinical use of powerful forms of vitamin A has induced leukemia cells to relinquish their malignant phenotype and enter a program of normal cellular differe...
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