Acute myeloid leukaemia (AML) is a haematological cancer with poor outcomes due to lack of efficacious targeted therapies. The Nuclear Factor Activated T Cells (NFAT) family transcription factors well characterised as regulator the cell cycle and differentiation in lineage. Recent evidence has demonstrated that NFAT members may have roles regulating AML leukemogenesis resistance therapy leukaem...

The most common acute hematological malignancy in adults is acute myeloid leukaemia (AML), accounting for more than 80% of cases in patients over 60 years of age [...].

Leukaemia has been reported' recently in association with apparently unrelated haematological malignancies in patients treated with cytotoxic drugs. These leukaemias are mainly acute myeloid or variants such as acute myelomonocytic3 or erythroleukaemia.' We describe a case of chronic granulocytic leukaemia (CGL) developing in a patient with a non-Hodgkin's lymphoma treated with alkylating agent...

The purpose of a classification is not only to group diseases with the same biological characteristics, but also to get insight into the pathogenesis and to define subgroups with different prognoses and different therapeutic approaches. In acute leukaemias the classification now most widely used is the French-American-British (FAB) classification as proposed in 1976, which was based on morpholo...

Chronic myelomonocytic leukaemia is an atypical myeloproliferative disorder with a natural history of progression to acute myeloid leukaemia, a complex and poorly understood response by the bone marrow to stress. Cardiac surgery activates many inflammatory cascades and may precipitate a systemic inflammatory response syndrome. We present a case of undiagnosed chronic myelomonocytic leukaemia wh...

In 130 cases of acute myeloid leukaemia in children below the age of 14 years in Great Britain, there were 21 cases in which the central nervous system was involved. The incidence and timing is similar to that of acute lymphoblastic leukaemia; in a small number of patients who received prophylactic treatment, involvement of the central nervous system was prevented.

Acute myeloid leukaemia (AML) is a clonal, malignant disease of hematopoietic tissue characterized by accumulation of abnormal cells, mainly leukaemic blasts in bone marrow and impaired production of normal hematopoietic cells. Leukaemia was discovered in 1845, roughly at the same time by two doctors, Rudolph Virchow, a young Berlin pathologist and a Scottish pathologist, John Hughes Bennett. T...

OBJECTIVES This study aimed to assess the incidence and trend of childhood leukaemia in Basrah. METHODS This was a hospital-based cancer registry study carried out at the Pediatric Oncology Ward, Maternity & Children's Hospital and other institutes in Basrah, Iraq. All children with leukaemia, aged 0 to 14 years diagnosed and registered in Basrah from January 2004 to December 2009 were includ...