background: environment of basrah is seriously contaminated with chemical leukomogens as a result of recent military conflicts. many studies in the past few years have reported an increase in the incidence of leukemia in basrah. this study was designed to study the risk and pattern of childhood leukemia in basrah, iraq, from 2003 to 2007.materials and methods: this hospital-based cancer registr...

Many systemic diseases are early indicated by oral manifestations. Among such systemic diseases Leukemia is one which shows characteristic oral manifestations. Acute myeloid leukemia (AML) is characterized by maturation arrest of myeloid cells which leads to increase in number of myeloblasts in the bone marrow and hemopoietic insufficiency. Patients with AML in general may present with a wide v...

ABSTRACT Three patients were diagnosed at our facility with therapy-related acute myeloid leukemia (t-AML) but had differing etiologies. Patient A was a 30-year-old male history of lymphoblastic in remission. The patient admitted to the hospital early 2019 for pain control and concurrent pancytopenia. bone marrow biopsy performed because concern relapsed disease. showed 96.6% blasts 95...

Acute myeloid leukemia (AML) is a clonal hematopoietic disease that arises from chromosomal and genetic aberrations in precursor cells. AML one of the most common types acute adults; however, it relatively rare overall, comprising about 1% all cancers. In last decade or so, numerous genome-wide association studies (GWAS) have been conducted to screen between hundreds thousands millions variants...

Background: Flow cytometric analysis of leukemias improves accuracy for distinguishing acute leukemias of myeloid and lymphoid origin. In rare cases, both myeloid and lymphoid antigens are expressed, creating ambiguity for lineage assignment and difficulties in diagnosis of leukemia. Aberrant antigen expression in acute myeloid leukemia (AML) is recognized to be a poor prognostic indicator. CD7...

Cutaneous presentation revealing acute myeloid leukemia (AML) is rare, and the prognosis poor. We report a case of an 11-month-old male who presented with cutaneous lesions present as diffuse purplish papulo-nodular lesions, M5 leukemia. Skin biopsy immunohistochemical examination, combined routine blood analysis bone marrow contributed to early diagnosis. However, despite intensive chemotherap...

Background & objective: Pancytopenia is the reduction in the number of all 3 major cellular elements of blood and leads to anemia, leukopenia, and thrombocytopenia. A wide variety of etiologies result in pancytopenia including leukemia, aplastic anemia, and megaloblastic anemia. The current study identified the different etiologies of pancytopenia base...

the TCR d gene rearrangements in AML show the same pattern as those in T-ALL,4 and occur more frequently in immature AML3,6 or in lymphoid antigen–(CD2, CD4, or CD7) positive (Ly1) AML.4 Because myeloid/NK cell precursor acute leukemia can be recognized as immature AML or Ly1 AML, the existence of the Dd2-Jd1 pattern of TCR d gene rearrangement in myeloid/NK cell precursor acute leukemia is con...

Lin28A is a highly conserved RNA-binding protein that concurs to control the balance between stemness and differentiation in several tissue lineages. Here, we report the role of miR-128a/Lin28A axis in blocking cell differentiation in acute myeloid leukemia (AML), a genetically heterogeneous disease characterized by abnormally controlled proliferation of myeloid progenitor cells accompanied by ...

FLT3 (fms-related tyrosine kinase 3) is a receptor tyrosine kinase class III that is expressed on by early hematopoietic progenitor cells and plays an important role in hematopoietic stem cell proliferation, differentiation and survival. FLT3 is also expressed on leukemia blasts in most cases of acute myeloid leukemia (AML). In order to determine the frequency of FLT3 oncogene mutations, we ana...