Kidney failure secondary to renal hemosiderosis has been reported in diseases with intravascular hemolysis, like paroxysmal nocturnal hemoglobinuria, and valvular heart diseases. We present here a case of hemosiderin induced acute tubular necrosis secondary to intravascular hemolysis from Clostridium difficile infection with possible role of supratherapeutic INR. We discuss the pathophysiology,...

INTRINSIC ACUTE RENAL FAILURE (ARF) THAT DOES NOT result from primary vascular, glomerular, or interstitial disorders has been ascribed to acute tubular necrosis and accounts for approximately 45% of cases of hospital-acquired ARF. While acute tubular necrosis usually is caused by ischemic (50%) or nephrotoxic (35%) injury to the kidney, the cause is often multifactorial. Unfortunately, neither...

purpose: to report a case of acute retinal necrosis following herpetic encephalitis. case report: a 25-year-old male presented with pain and visual loss in his left eye. he had herpetic encephalitis 1 month prior to the visual symptoms. ophthalmologic examination and paraclinical evaluation disclosed acute retinal necrosis. conclusion: herpetic encephalitis may be a risk factor for acute retina...

BACKGROUND Human leukocyte antigen (HLA)-G is a nonclassical HLA class I molecule that displays strong immune-inhibitory properties and has been associated with allograft acceptance. However, there are conflicting data on the correlation of soluble HLA-G (sHLA-G) and acute rejection and no data on the correlation with acute tubular necrosis in kidney transplantation. OBJECTIVE To evaluate the...

Acyclovir is an effective antiviral agent in herpes simplex and varicella-zoster infections treatments. However, it may cause serious side effects. This case study reports a patient who developed both acute tubular necrosis neurotoxicity induced by intravenous acyclovir recovered promptly after hemodialysis. Caution needed monitoring patients receiving acyclovir. Eliminating with early diagnosi...

Renal complications from snakebite result in high mortality and morbidity. Acute kidney injury (AKI) occurs in 5-30% of cases. Renal manifestation could include acute tubular necrosis, cortical necrosis, interstitial nephritis, glomerulonephritis, and vasculitis. We present a case of thrombotic microangiopathy (TMA) resulting in renal cortical necrosis. Renal biopsy showed fibrin thrombi in glo...

BACKGROUND/AIMS Interferon treatment of malignant or viral diseases can be accompanied by various side-effects including nephro-toxicity. METHODS We report on a 68-year-old Caucasian male who received dual therapy with pegylated interferon 2a plus ribavirin for chronic hepatitis C. RESULTS After three months of antiviral therapy, the patient developed acute kidney failure (serum creatinine ...

The urinary sediment was examined by light microscopy in 65 consecutive inpatients with renal insufficiency (not due to pre- or postrenal factors) referred to a nephrology consult service for evaluation. In the 60 patients in whom a single diagnosis was reached, the sediments of 34 (57%) contained an easily recognized cell, which we have called the "bubble cell". These cells were bizarre, large...

Isoflurane, the most widely used inhalational anesthetic, releases inorganic fluoride during its metabolism by the cytochrome P450 system. Recent experimental data indicate that when cultured proximal tubular cells are exposed to inorganic fluoride, they become relatively resistant to myoglobin- and ATP depletion-mediated attack. The present study was undertaken to assess whether isoflurane ane...

OBJECTIVE To investigate the clinicopathological significance of CD206-positive macrophage expression in patients with acute tubulointerstitial disease, including acute tubular necrosis (ATN) and acute interstitial nephritis (AIN). METHODS Renal tissue samples from patients with ATN (n=10), AIN (n=10), and minimal change disease (MCD, as disease control, n=8) as well as tissue from normal con...