Background Neoplastic adenomatous polyps generating from the epithelial cells are considered benign tumors. Adenomatous polyps are common in western countries and it can take seven to 10 or more years for an adenoma to evolve into cancer.  The Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway, is a signaling pathway that controls organ size in animals through the r...

  Ectopic paratliyroid adenoma might create a clinical dilemma in patients with hypercalcemia. Radioisotopic scan is a sensitive and noninvasive method which can be useful in these patients. In this report a case of ectopic parathyroid adenoma is presented and the usefulness of TC-99m-MIBI scintigraphy as compared with other modalities is discussed.

BACKGROUND Although gastric adenoma is widely accepted as a precursor of gastric cancer, pre-existing adenoma is not always detected in gastric cancer patients. OBJECTIVE To investigate the clinical characteristics of early gastric cancer (EGC) arising from adenoma, compared with those of EGC without pre-existing adenoma. METHODS Patients who underwent endoscopic resection for EGC at a sing...

purpose: to study early treatment outcomes and complications of gamma knife radiosurgery (gkrs) in patients with functional and nonfunctional adenomas. methods: one hundred patients with a pituitary adenoma who were treated between 2011 and 2014 at iran gamma knife center were studied. the patients were followed up at least 2 years. radiosurgery was performed using the leksell gamma unit. the m...

an ectopically placed parathyroid in the mediastinum is a rare cause of persistent or recurrent primary hyperparathyroidism. they are rarely in a huge size. we report a case of a 70-year-old man with a history of total parathyroidectomy and thymectomy presented with a lack of appetite, nausea, and generalized bone pain, polydipsia and a calcium level of 14.4 mg/dl. 99m tc-sestamibi scintigraphy...

Metformin and insulin differently affect the risk of colon cancer in type 2 diabetic patients, however their effects on colon adenoma is not clear. PubMed, ISI, Scopus and Cochrane databases were searched for studies reporting. The outcomes were total adenoma; advanced adenoma and recurrent adenoma. Traditional and Bayesian meta-analysis were conducted via random-effects models. Odds ratios (OR...

a rare case of squamous cell carcinoma ex pleomorphic adenoma in maxillary sinus is presented. the patient is a 50-year-old woman presenting with a slow-progressive swelling in left side of her face that she has noticed 2 years earlier. the lesion was not painful and caused asymmetry and mild exophthalmos. microscopic examination revealed that the tumor was composed of two components partly of ...

a 19-year-old girl referred to our clinic complaining of a painless lump on the left side of her tongue.  the patient had no history of dysphagia, lingual paresthesia or bleeding. physical examination revealed the presence of multiple enlarged lymph nodes on the left side of her neck.  histopathology of lingual mass and lymph nodes showed pleomorphic adenoma.  to our knowledge, this is the firs...

Background: Visfatin is an adipocytokine secreted by visceral adipose tissue. It has been shown that adipocytokines may contribute to the induction of carcinogens and progression of tumors. Previously, we found a significant increase in the visfatin serum level in colorectal cancer patients. Herein, we investigated if this cytokine increases in patients with colorectal adenoma as a precursor of...