To study the aggregation activity of platelets in patients with ischemic heart disease depending on long-term intake acetylsalicylic acid (ASA). Material and methods. The included: 116 coronary artery stable angina pectoris, taking a standard dose aspirin 75 mg/day. during various terms. Patients SSN were divided into 4 groups according to duration ASA. Platelet was measured using laser platele...

Fractional flow reserve (FFR) is increasingly used to guide myocardial revascularisation. However, supporting evidence regarding its use originates from studies that have enrolled mainly patients with stable angina, while patients with acute coronary syndromes (ACS) have not been included. Notably, multifactorial microvascular dysfunction and an increased sympathetic tone in patients with ACS m...

out coronary disease. Cathet Cardiovasc Diagn 3: 47, 1977 14. Schnaar RL, Sparks HV: Response of large and small coronary arteries to nitroglycerin, NaNO^, and adenosine. Am J Physiol 22: 223. 1972 15. Harder DR, Belardinelli L, Sperelakis N, Rubio R, Berne RM: Differential effects of adenosine and nitroglycerin on the action potentials of large and small coronary arteries. Circ Res 44: 176, 19...

BACKGROUND The results of percutaneous coronary intervention (PCI) for saphenous vein graft (SVG) disease are limited by distal embolisation and no-reflow which occurs in 10-43% of cases. AIM To examine the role of a new protocol of adenosine administration during PCI in SVG on immediate angiographic results and clinical course. METHODS A prospective, single-centre, randomised placebo-contr...

In this study the uptake and metabolism of adenosine by mitochondria has been investigated. Incubation of CEM cells mitochondria preparation with [3H] -adenosine showed substantial uptake and metabolism of adenosine. Adenosine was both anabolized to AMP, ADP and ATP, and also catabolized to inosine. The highest concentration of metabolites in extracted mitochondria was due to AMP. The mito...

abstract despite sophisticated conventional medical treatment and the continued development and improvement of coronary revascularization modalities in recent years, a significant number of patients still suffer from refractory angina pectoris and cannot be successfully managed. advances in therapeutic options have led to an increase in the average of life expectancy even in such no-option pati...

BACKGROUND In patients with angina and nonobstructive coronary artery disease (NOCAD), confirming symptoms due to coronary microvascular dysfunction (CMD) remains challenging. Cardiac magnetic resonance (CMR) assesses myocardial perfusion with high spatial resolution and is widely used for diagnosing obstructive coronary artery disease (CAD). OBJECTIVES The goal of this study was to validate ...

in this study the uptake and metabolism of adenosine by mitochondria has been investigated. incubation of cem cells mitochondria preparation with [3h] -adenosine showed substantial uptake and metabolism of adenosine. adenosine was both anabolized to amp, adp and atp, and also catabolized to inosine. the highest concentration of metabolites in extracted mitochondria was due to amp. the mitochond...

OBJECTIVES This study evaluated the usefulness of washout rate analysis in adenosine triphosphate(ATP) stress thallium-201 scintigraphy for the diagnosis of vasospastic angina. METHODS This study included 76 patients with vasospastic angina and 18 normal controls undergoing coronary arteriography. If significant coronary artery stenosis (> or = 50%) was pointed out, the subject was excluded f...