Injective transfer of autologous aspirated fat is a popular option for soft tissue augmentation, but several issues require attention, including unpredictability and a low survival rate due to partial necrosis. In this study, histologic features and yield of adipose-derived stromal (stem) cells (ASCs) were compared between human aspirated fat and excised whole fat. Aspirated fat contained fewer...

OBJECTIVES The current study tested the hypothesis that glucose utilization differs between visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), and investigated potential mechanisms for such a finding. BACKGROUND VAT burden correlates better with cardiovascular risk than does SAT burden. Beyond volumetric measurement, glucose uptake in adipose tissue (AT) might reflect metabo...

Adipose-derived stem cells are increasingly targeted as an autologous source of multipotent cells in regenerative medicine. Specifically, reconstructive lipotransfer procedures combine freshly harvested adipose tissue with ADSCs to improve vascularization and tissue grafting [1]. Furthermore, ADSCs offer a wide array of potential uses in tissue reengineering and cell therapies including wound h...

Postmastectomy pain syndrome (PMPS) is defined as chronic lasting more than 3 months after surgery. PMPS reduces the quality of life for patients and affects their daily life. Although pathogenesis has not been clearly elucidated, it strongly suggestive neuropathic caused by damage to intercostobrachial nerve. While previous studies have used stromal vascular fraction (SVF)-enriched fat grafts ...

Adipose tissue development is associated with neovascularization, which might be exploited therapeutically. We investigated the neovasculogenesis antigenic profile and kinetics in adipose tissue-derived stromal cells (ADSCs) to understand the potential of ADSCs to generate new vessels. Murine and human visceral adipose tissues were processed with collagenase to obtain ADSCs from the stromal vas...

Aspirated fat contains unnecessary components such as water, oil, and blood cells. For better outcomes, tissue purification and condensation are useful, especially when injection volume to the recipient site is limited. Because aspirated fat is relatively poor in adipose-derived stem/stromal cells (ASCs), ASC condensation seems important for obtaining better regeneration and retention. Reducing...