We have studied the self-adjointness of generalized MIC-Kepler Hamiltonian, obtained from the formally self-adjoint generalized MIC-Kepler Hamiltonian. We have shown that for l̃ = 0, the system admits an 1-parameter family of self-adjoint extension and for l̃ 6= 0 but l̃ < 1 2 , it has also an 1parameter family of self-adjoint extension.