Glucocorticoid (GC) is an adrenal steroid with diverse physiological effects. It undergoes a robust daily oscillation, which has been thought to be driven by the master circadian clock in the suprachiasmatic nucleus of the hypothalamus via the hypothalamus-pituitary-adrenal axis. However, we show that the adrenal gland has its own clock and that the peripheral clockwork is tightly linked to ste...

SUMMARY Two new inbred lines of Syrian hamsters are described in their 13th , to 20th and 24th to 34th generations of brother-sister mating. One of the two lines, identified as BlO 4.24, shows a high incidence of adrenal tumors (in about 50% of the animals). The other, BlO 45.5, shows a significantly lower incidence (in about 17% of the animals). Histologically, these were the types of adrenal ...

We report a 32-year-old female case of a right adrenal gland mass detected on CT scan at medical checkup. CT and MRI showed a mass of 5.1 cm made of fat and calcification in the right adrenal gland, leading to the clinical diagnosis of adrenal myelolipoma. Because of its relatively large size and the patient's desire, the patient underwent gasless single-port retroperitoneoscopic adrenalectomy ...

Adrenal gland insufficiency - the clinical manifestation of deficient production or action of adrenal steroids - is a life-threatening disorder. Among many factors which can predispose to primary adrenal failure, an autoimmune adrenalitis and infectious agents play a major role. The initial host defense against bacterial infections is executed primarily by the pattern recognition receptors, e.g...

In ageing human adrenal glands there occur some morphological changes which result in alterations of their cortex endocrine function. Glucocorticoid-excreting cells in the zona glomerulosa live longer than androgen-producing cells in the zona reticularis, which undergo significant apoptosis. Therefore, in elderly humans cortisol levels are normal (significantly higher than at young age), while ...

Endogenous cannabinoids are important signaling molecules in neuroendocrine control of homeostatic and reproductive functions including stress response and energy metabolism. The hypothalamic paraventricular and supraoptic nuclei have been shown to release endocannabinoids, which act as retrograde messengers to modulate the synaptic release of glutamate during stress response. This study endeav...

conclusions in this study we showed that eft, measured by echocardiography is higher in subjects with ai when compared to healthy controls. epicardial fat thickness had the best independent correlation with ai in multiple logistic regression analysis. incidentaloma is also associated with increased left ventricular mass index and cimt. adrenal incidentaloma patients may show early cardiac chang...

One reference to the transplantation of an adrenal cortical tumor of the mouse has been found in the literature. Dalton, Edwards, and Andervont (1) reported on a spontaneous, transplantable, adrenal cortical tumor in a female strain C mouse 24 89 months of age. They presented evidence that this neoplasm originated from relatively undifferentiated cells of the adrenal cortex. The failure to find...