introduction: to evaluate the camp -mediated ibmx (3-isobutyle -1-methyl xanthin) and db-camp (dibutyryl camp) effects on differentiation of human embryonic stem cells (hescs) into nerve cells were the objectives of this study. methods: we have used royan h1 hesc- derived embryoid bodies with four treatment groups: six days treatment with ibmx (5×10 -4m) and db-camp (10 -9m) (referred to as cam...

The threshold sensitivity of cardiovascular tissues to alpha-adrenergic stimulation is determined largely by the affinity of alpha-adrenergic receptors for agonists. To determine whether changes in alpha-adrenergic receptor affinity could contribute to the regulation of cardiac and vascular responsiveness, we used the alpha-adrenergic-selective radioligands, [3H]prazosin, [3H]-WB-4101, and [3H]...

The threshold sensitivity of cardiovascular tissues to a-adrenergic stimulation is determined largely by the affinity of a-adrenergic receptors for agonists. To determine whether changes in a-adrenergic receptor affinity could contribute to the regulation of cardiac and vascular responsiveness, we used the a-adrenergic-selective radioligands, [H]prazosin, [H]-WB-4101, and [H]rauwalscine, to stu...

Dobutamine and its stereoisomers were evaluated for alpha and beta adrenergic activities in vitro. The racemate and the (--)-isomer were found to be potent partial agonists of alpha adrenergic receptors in rat aorta. The (+)-isomer lacked alpha agonist activity. The affinities of (+/-)-, (+)- and (--)-dobutamine for the alpha adrenergic receptor were high (--log KB values of 7.01, 7.02 and 7.07...

Lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) are highly prevalent in older men. Medical therapy is the first-line treatment for LUTS associated with BPH. Mainstays in the treatment of male LUTS and clinical BPH are the α(1)-adrenergic receptor antagonists. Silodosin is a new α(1)-adrenergic receptor antagonist that is selective for the α(1A)-adrenergic ...

BACKGROUND A-kinase Anchoring Protein AKAP5 and AKAP12 both dock to the beta2-adrenergic receptor, the former constitutively, the latter dynamically in response to activation of the receptor with agonist. RESULTS In the current work we analyze the ability of each AKAP to contribute to two downstream signaling events, the activation of mitogen-activate protein kinase and the resensitization/re...

The objective was to determine whether recombinant bovine somatotropin (rbST) enhanced live performance,skeletal muscle biological activity, and beta-adrenergic receptor expression of feedlot heifers during the finishing phase. Heifers (n = 16; initial body weight 457 ± 3 kg) were randomly assigned pens (4 pens/treatment; 2 heads/pen) treatment: (1) no rbST (Control); (2) 500 mg/hd sometribove ...

ABSTRACT Hypertension causes significant mortality and morbidity around the world. The β-adrenergic blockers are one of most commonly prescribed hypertension medications. Several with different pharmacological qualities have been developed, which may be grouped into three generations based on differences in properties. In this narrative review, we addressed evidence-based literature about role ...