Advanced maternal age is associated with negative offspring health outcomes. This interpretation often relies on physiological processes related to aging, such as decreasing oocyte quality. We use a large, population-based sample of American adults to analyze how selection and lifespan overlap between generations influence the maternal age-offspring adult health association. We find that offspr...

introduction preterm birth is still a major health problem throughout the world. preterm birth results in 75% of neonatal mortality. we sought to identify risk factors which cause preterm birth. materials and methods this cross-sectional study assessed all preterm neonates born in asali hospital in khorram abad (either by nvd or c/s) during the first 6 months of 2007. sampling method was census...

this study examines the association of father's and mother's age with the severity of inattention and hyperactivity/impulsivity. participants are 470 children with attention deficit hyperactivity disorder (adhd) diagnosed according to dsm-iv diagnostic criteria. moreover, parents reported the severity of adhd symptoms through completing adhd checklist. mother's and father's age was associated w...

BACKGROUND Fetal sex and maternal age are each known to affect outcomes of pregnancies. The objective of the present study was to investigate the influence of the combination of maternal age and fetal sex on pregnancy outcomes in term and post-term singleton pregnancies. MATERIAL AND METHODS This was a retrospective study on term singleton pregnancies delivered between 2004 and 2008 at the Ch...

OBJECTIVE To evaluate the association of maternal age with occurrence of fetal chromosomal abnormalities in Korean pregnant women of advanced maternal age (AMA). METHODS A retrospective review of the amniocentesis or chorionic villous sampling (CVS) database at Gangnam and Bundang CHA Medical Centers, between January 2001 and February 2012, was conducted. This study analyzed the incidence of ...

Advanced maternal age at birth is considered a major risk factor for birth outcomes. It is unclear to what extent this association is confounded by maternal characteristics. To test whether advanced maternal age at birth independently increases the risk of low birth weight (<2,500 g) and preterm birth (<37 weeks' gestation), we compared between-family models (children born to different mothers ...

Down syndrome (DS), trisomy 21, is the most common chromosomal syndrome that affects one in 600800 live births. The advanced maternal age is the only well known risk factor to cause DS. Our study revealed that many young mothers produced DS children than advanced age mothers in India. A total of 150 suspected DS cases were investigated cytogenetically. Randomly selected 200 healthy families in ...

Background: Preimplantation genetic aneuploidy screening (PGS) has been performed during the last decade as a way of enhancing embryo selection in patients with an increased incidence of embryonic numerical chromosome abnormalities (advanced maternal age, recurrent miscarriage, and recurrent implantation failure). It has been proposed that the replacement of euploid embryos in these patients wo...