INTRODUCTION Spontaneous reporting of adverse drug reactions (ADRs) is used for continuous risk-benefit evaluation of marketed pharmaceutical products and for signal detection. The Adverse Drug Event Manager (ADEM) is a service offered to clinicians employed at hospitals in the Capital Region of Denmark. The ADEM assists healthcare professionals in reporting suspected ADRs to the Danish Health ...

adverse drug reaction (adr) is one of the most life threatening problems, and the economic burden of adr is considerable. the main objective of this study was to assess the attitude of the kerman health system staff, to evaluate their knowledge of the spontaneous reporting system and to identify the reasons for low reporting rate. in this descriptive study, a persian translated questioner was u...

background: controversy persists over the potential benefits/harms of opium consumption in coronary heart disease. this study investigated the association between 12 months' major adverse cardiac events (mace) and pre-procedural opium consumption among patients undergoing percutaneous coronary intervention (pci). methods: retrospectively, 1545 consecutive men who underwent pci between 21 st   j...

errors prevention and patient safety in transfusion medicine are a serious concern. errors can occur at any step in transfusion and evaluation of their root causes can be helpful for preventive measures. root cause analysis as a structured and systematic approach can be used for identification of underlying causes of adverse events. to specify system vulnerabilities and illustrate the potential...

We systematically compared the adverse effects of cancer drugs to detect event outliers across different clinical trials using a data-driven approach. Because many cancer drugs are toxic to patients, better understanding of adverse events of cancer drugs is critical for developing therapies that could minimize the toxic effects. However, due to the large variabilities of adverse events across d...