The first general anaesthetics resulted from the action of one drug, either ether or chloroform. Today, general anaesthetics are usually complex "cocktails" and it is not uncommon for several different drugs to be given. Each of these has a distinct, predictable pharmacological action. Thus, when an unpredicted reaction occurs shortly after the injection of a drug, one possible explanation is t...

a bstract background: medication errors and adverse drug events of high alert medication are one of the major problems in therapeutic system. the purpose of the present study was to investigate ‎the effect of clinical supervision model on high alert medication safety in intensive care units nurses. materials and methods: this was a quasi-experimental study conducted on 32 nurses of intensive ca...

BACKGROUND Adverse events related to drugs occur frequently among inpatients, and many of these events are preventable. However, few data are available on adverse drug events among outpatients. We conducted a study to determine the rates, types, severity, and preventability of such events among outpatients and to identify preventive strategies. METHODS We performed a prospective cohort study,...

Introduction. Adverse events (AE) in the process of pharmacotherapy can have direct consequences on health and life a patient. Factors leading to AE are categorized human systematic ones. Among latter ones, most important significant shortages nursing staff as well stress, fatigue Occupational Burnout Syndrome. Reporting is crucial pillar prevention adverse drug administration nursing.
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OBJECTIVES The purposes of this study were to develop a pediatric-focused tool for adverse drug event detection and describe the incidence and characteristics of adverse drug events in children's hospitals identified by this tool. METHODS A pediatric-specific trigger tool for adverse drug event detection was developed and tested. Eighty patients from each site were randomly selected for retro...

Background: Hemorrhagic events are amongst the major adverse effects of injectable anticoagulants such as heparin and enoxaparin. This necessitates close monitoring of their use for clinically relevant drug-drug interactions. Aim: To study the rate of hemorrhagic events, the anatomical site, and the severity of the hemorrhage in patients receiving heparin or enoxaparin in combination with clop...