P clinical assessment is critical to identify patients who will benefit from treatment for localized prostate cancer. Although initial efforts to stratify patients into good and poor risk categories have focused on stage, grade, and prostate-specific antigen (PSA) levels, studies are currently underway to improve on these clinical parameters by incorporating molecular markers of aggressive dise...

background: oxaliplatin (ox) significantly enhanced the antitumor activity of 5-fu in patients with advanced colorectal cancer and recently some phase ii trials have evaluated the feasibility and efficacy of oxaliplatin in neoadjuvant setting for treatment of locally advanced rectal cancer. on the other hand various studies have demonstrated that the overexpression of thymidylate synthase (ts) ...

Hiccups are common, typically limited, and rarely present with adverse complications. In the context of persistent or intractable episodes, however, hiccups may signal a more serious underlying cause. Here, we present an unexpected and pathologic case of hiccups in a patient who was ultimately diagnosed with renal abscesses.

Please cite this article as: John V. Hegde, Darlene Veruttipong, Jonathan W. Said, Robert E. Reiter, Michael L. Steinberg, Christopher R. King, Amar U. Kishan, Prostate Cancer Antigen 3 (PCA3) Score Does Not Predict for Adverse Pathologic Features at Radical Prostatectomy or for Progression-Free Survival in Clinically-Localized, Intermediateand High-Risk Prostate Cancer, Urology (2017), http://...

background breast cancer is the most common cancer among women worldwide. based on the latest iranian national cancer department report, the total number of women registered with breast cancer was 6976 cases during 2007. five year survival is one of the indicators used for evaluation of the quality for care to different types of malignancies including breast cancer. objectives the aim of this s...

Eight inherited neurodegenerative diseases are caused by genes with expanded CAG repeats coding for polyglutamine domains in the disease-producing proteins. The mechanism by which this expanded polyglutamine domain causes neurodegenerative disease is unknown, but nuclear and cytoplasmic polyglutamine protein aggregation is a common feature. In transfected COS7 cells, expanded polyglutamine prot...