In this study, new composite materials of montmorillonite, biochar, or aerosil, containing metal–organic frameworks (MOF) were synthesized in situ. Overall, three different MOFs—CuBTC, UTSA-16, and UiO-66-BTEC—were used. Obtained adsorbents characterized using powder X-ray diffraction, thermogravimetric analysis, nitrogen adsorption porosimetry, scanning electron microscopy, energy-dispersive s...

Rivaroxaban (RN) is a recently developed potent oral anticoagulant. The aim of the present study envisages compatibility studies rivaroxaban with crospovidone, sodium startch glycolate, magnesium stearate, talc, microcrystalline cellulose, aerosil, HPMC K100 M, croscarmellose using Differential scanning calorimeter and FTIR spectrophotometer. DSC thermograms, physical mixture individual pharmac...

We studied the structure and the dynamics of a nanocolloidal silica gel dispersed in an organic solvent [octylcyanobiphenyl (8CB)] as a function of the silica density by x-ray intensity fluctuation spectroscopy (XIFS). The silica density of the dispersed aerosil gel samples ranged from 0.03 to 0.20 g cm-3 and the autocorrelation of the silica scattering was probed over the q range from 0.03 to ...

Surface solid dispersion with insoluble carriers is considered a recently developed technique, widely applied for the enhancement of solubility and dissolution of poorly water soluble drugs. The objective of this research article is to study the effect of surface solid dispersion of ketoprofen with colloidal silicon dioxide (Aerosil 200) on the dissolution rate. Surface solid dispersion (Adsorb...

The effect on the nematic to smectic-A transition in octylcyanobiphenyl (8CB) due to dispersions of hydrogen-bonded silica (aerosil) particles is characterized with high-resolution x-ray scattering. The particles form weak gels in 8CB creating a quenched disorder that replaces the transition with the growth of short-range smectic correlations. The correlations include thermal critical fluctuati...

Aim. To develop the content of adhesive composition, being one stages in developing transdermal therapeutic system with anti-inflammatory action. Materials and methods. Using organoleptic research methods, properties affecting process applying to base subsequently quality finished product were studied. Color, consistency homogeneity determined visually, features mass recorded. determine optimal...

Objective: The objective of the present study was to compare release effect Luliconazole from different polymeric (Hydrophilic and Hydrophobic) microsponges prepared using varying concentrations. best microsponge selected incorporated into gel (Natural synthetic) drug is determined compared with marketed formulation.
 Methods: Polymers such as EC, HPMC, Eudragit RSPO PVA emulsifier, solven...

The objective of this study was to evaluate the effect of formulation variables on the release properties, floating lag time, and hardness, when developing floating tablets of Ranitidine hydrochloride, by the statistical optimization technique. The formulations were prepared based on 3(2) factorial design, with polymer ratio (HPMC 100 KM: Xanthan gum) and the amount of aerosil, as two independe...