BACKGROUND BRAF/MEK inhibitor therapy improves outcomes in BRAF V600E- and V600K-mutated unresectable or metastatic melanoma. However, these regimens are associated with adverse events (AEs) that may lead to unnecessary drug modifications and discontinuations or potentially serious sequelae. In addition, drug-drug interactions (DDIs) may result in AEs or altered therapeutic efficacy.
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An AES algorithm can be implemented in software or hardware but hardware implementation is more suitable for high speed applications.AES is most secure security algorithm to maintain safety and reliability of date transmission for this key size is important. And here used AES-256 bit.The main goal of paper is AES hardware implementation to achieve less area and low power consumptions also to ac...

This work exposes further vulnerabilities in virtualized cloud servers by mounting Cross-VM cache attacks in Xen and VMware VMs targeting AES running in the victim VM. Even though there exists a rich literature on cache attacks on AES, so far only a single work, demonstrating a working attack on an ARM platform running a L4Re virtualization layer has been published. Here we show that AES in a n...

Recently, much research has been conducted for security for wireless sensor networks and ubiquitous computing. Security issues such as authentication and data integrity are major requirements to construct sensor network systems. Advanced Encryption Standard (AES) is considered as one of candidate algorithms for data encryption in wireless sensor networks. In this paper, we will present the hard...

The Square attack as a means of attacking reduced round variants of AES was described in the initial description of the Rijndael block cipher. This attack can be applied to AES, with a relatively small number of chosen plaintext-ciphertext pairs, reduced to less than six rounds in the case of AES-128 and seven rounds otherwise and several extensions to this attack have been described in the lit...

In this paper, we point out a new weakness of the AES key schedule by revisiting an old observation exploited by many known attacks. We also discover a major cause for this weakness is that the column-by-column word-wise property in the key schedule matches nicely with the MixColumns operation in the cipher’s diffusion layer. Then we propose a new key schedule by minor modification to increase ...

INTRODUCTION The growing problem of antibacterial resistance resulted in an increased interest in fosfomycin, especially its parenteral formulation. We reviewed fosfomycin safety profile using the Food and Drug Administration Adverse Event (AE) Reporting System (FAERS) and published literature. METHODS We conducted a FAERS search and disproportionality analysis of all fosfomycin-associated AE...

BACKGROUND Determination of drug safety and tolerability is usually based on the frequency of certain key adverse events (AEs) rather than the frequency of all-grade toxicities. We assessed the reporting of key AEs in oncology randomized, controlled trials (RCTs) and compared that with the expectations of the European Organization for Research and Treatment of Cancer (EORTC) membership. MATER...

PURPOSE Defining the tolerability and safety profile of recently marketed antiepileptic drugs, such as lacosamide (LCM), is a prerequisite for their optimal utilization in clinical practice. We aimed to identify any adverse event (AE) associated with LCM treatment by conducting a systematic review and meta-analysis of all available randomized controlled trials (RCTs). We also evaluated the asso...

There are various methods to collect adverse events (AEs) in clinical trials. The methods how AEs are collected in vaccine trials is of special interest: solicited reporting can lead to over-reporting events that have little or no biological relationship to the vaccine. We assessed the rate of AEs listed in the package insert for the virosomal hepatitis A vaccine Epaxal(®), comparing data colle...