introduction: the brain renin-angiotensin system (ras) has been reported having a pathological role in age-related impairment in learning and memory. therefore, angiotensin converting enzyme inhibitors (acei) are expected to have positive effects on memory. longtime treatment with captopril (an angiotensin converting enzyme inhibitor) significantly attenuates the age-related impairment in learn...

we and other studies have elucidated single molecules that can attenuate aging and extend longevity. indeed, these molecules could prevent age-associated diseases simultaneously and probably extending healthy-life spans. in this review, we discuss recent advances, controversies, opportunities and challenges surrounding ursolic acid (ua) in relationship with aging. in this regard, ua also known ...