نتایج جستجو برای: aj
تعداد نتایج: 3643 فیلتر نتایج به سال:
The Ashkenazi Jewish (AJ) population is important in genetics due to its high rate of Mendelian disorders. AJ appeared in Europe in the 10th century, and their ancestry is thought to comprise European (EU) and Middle-Eastern (ME) components. However, both the time and place of admixture are subject to debate. Here, we attempt to characterize the AJ admixture history using a careful application ...
1. APPROXIMATE TOP-K Let {e1, e2, . . . , el} be a set of distinct records in a database, with unique IDs {id1, id2, . . . , idl}. Let A1, A2, . . . , Ap be a set of distinct attributes for each record. For every record ei, the attribute Aj is zero or some positive value. We denote the value of the attribute Aj of record ei by Aj(ei). The sum of the attributes of ei is denoted by Ni = ∑ j Aj(ei...
Consider rolling a die with k sides, labeled a1, a2, ..., and ak, respectively. Let P(aj) be the ‘probability’ that a particular side aj appears after rolling the die. Before attempting to calculate P(aj), it is necessary to clarify the meaning of the word ‘probability’. In other words, we must specify what the number P(aj) quantifies. In statistics, the concept of ‘probability’ is formally int...
Modulation of cell-cell adherens junctions by surface clustering of the N-cadherin cytoplasmic tail.
Cadherins mediate the formation of cell-cell adherens junctions (AJ) by homophilic interactions through their extracellular domains as well as by interacting with the actin cytoskeleton via their cytoplasmic portions. Cadherin clustering initiates cytoplasmic signaling that results in the assembly of structural components into cell-cell AJ. To elucidate the function of the cytoplasmic tail of c...
Tissue morphogenesis requires assembling and disassembling individual cell-cell contacts without losing epithelial integrity. This requires dynamic control of adherens junction (AJ) positioning around the apical domain, but the mechanisms involved are unclear. We show that atypical Protein Kinase C (aPKC) is required for symmetric AJ positioning during Drosophila embryogenesis. aPKC is dispensa...
Proof of Proposition 1. Suppose an attribute value ai is not recorded in any of the data sources S1 through Sn for an entity instance. Then, from Assumptions 1 and 2 in the paper, we have P A= ai AS1 = ak AS2 = al ASn = atW i = k i = l i = t = P AS1 = ak A= ai P AS2 = al A= ai × · · ·×P ASn = at A= ai P AS1 = ak AS2 = al ASn = at P A= ai = 1−R A S1 / m− 1 1−RS2 / m− 1 × · · ·× 1−RSn / m− 1 P AS...
We recently isolated a novel actin filament (F-actin)-binding protein, afadin, that has two isoforms, l- and s-afadins. l-Afadin is ubiquitously expressed and specifically localized at zonula adherens (ZA) in epithelial cells and at cell-cell adherens junction (AJ) in nonepithelial cells, whereas s-afadin is abundantly expressed in neural tissue. l-Afadin has one PDZ domain, three proline-rich ...
We performed a three-phase genome-wide association study (GWAS) using cases and controls from a genetically isolated population, Ashkenazi Jews (AJ), to identify loci associated with breast cancer risk. In the first phase, we compared allele frequencies of 150,080 SNPs in 249 high-risk, BRCA1/2 mutation-negative AJ familial cases and 299 cancer-free AJ controls using chi(2) and the Cochran-Armi...
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