Acute lung injury (ALI) remains a major cause of morbidity and mortality in critically ill patients. Despite improved understanding of the pathogenesis of ALI, supportive care with a lung protective strategy of mechanical ventilation remains the only treatment with a proven survival advantage. Most clinical trials in ALI have targeted mechanically ventilated patients. Past trials of pharmacolog...

Acute lung injury (ALI) is a critical illness syndrome with a mortality rate of 25-40%. Despite recent advances of our understanding of the pathophysiology of ALI, no pharmacologic therapies have been proven effective. The key pathogenesis of ALI is the activation of the coagulation cascade and impaired fibrinolysis, resulting in extensive fibrin and hyaline membrane deposition. Activated prote...

We solve the integral equation describing the propagation of light in an isothermal plane-parallel atmosphere of optical thickness τ∗, adopting a uniform thermalization parameter ǫ. The solution given by the ALI method, widely used in the field of stellar atmospheres modelling, is compared to the exact solution. Graphs are given that illustrate the accuracy of the ALI solution as a function of ...

A study of 50 sugar maples {Acer saccharum) along Gates Mills Boulevard in Gates Mills, Ohio, showed that a tree's sap-sugar concentration tended to increase with decreasing tree health and increasing soil salt concentration. Relative tree health was determined by growth ring analysis. Salt concentration in soil was determined by measuring soil extract conductivity. Extract conductivity correla...

26. M. Ramkumar and A. N. Akansu, IEEE 2nd Workshop Multimedia Signal Process. Dec. 1998, pp. 267–272. 27. M. Ramkumar and A. N. Akansu, SPIE Multimedia Syst. Appl. 3528, 482–492 (1998). 28. S. D. Servetto, C. I. Podilchuk, and K. Ramachandran, IEEE Int. Conf. Image Process. 1, 445–448 (1998). 29. A. Cohen and A. Lapidoth, Proc. Int. Symp. Inf. Theory, June 2000, p. 48. 30. P. Jessop, Int. Conf...

The genetic basis of acute lung injury (ALI) is poorly understood. The myosin light chain kinase (MYLK) gene encodes the nonmuscle myosin light chain kinase isoform, a multifunctional protein involved in the inflammatory response (apoptosis, vascular permeability, leukocyte diapedesis). To examine MYLK as a novel candidate gene in sepsis-associated ALI, we sequenced exons, exon-intron boundarie...

The acute respiratory distress syndrome (ARDS)/acute lung injury (ALI) was described 30 yr ago, yet making a definitive diagnosis remains difficult. The identification of biomarkers obtained from peripheral blood could provide additional noninvasive means for diagnosis. To identify gene expression profiles that may be used to classify patients with ALI, 13 patients with ALI + sepsis and 20 pati...

INTRODUCTION Beta2 agonists have several properties that could be beneficial in acute lung injury (ALI). We therefore chose to study the effect of inhaled beta2 agonist use (salbutamol) on duration and severity of ALI. METHODS We undertook a retrospective chart review of 86 consecutive mechanically ventilated patients with ALI, who had varying exposure to inhaled salbutamol. The cohort was di...

INTRODUCTION Our purpose was to investigate variation within the IL-32 promoter and gene, and susceptibility to and outcomes from infection associated acute lung injury (ALI). METHODS Retrospective case-control study involving healthy individuals (controls) and patients (cases) with infection-associated ALI. Two hundred fifty-eight healthy normal controls and 251 patients with infection-assoc...