The Th17 cytokines interleukin-17A (IL-17A), IL-17F, and IL-22 are critical for the lung immune response to a variety of bacterial pathogens, including Klebsiella pneumoniae. Th2 cytokine expression in the airways is a characteristic feature of asthma and allergic airway inflammation. The Th2 cytokines IL-4 and IL-13 diminish ex vivo and in vivo IL-17A protein expression by Th17 cells. To deter...

Chronic exposure to farm environments is a risk factor for nonallergic lung disease. In contrast to allergic asthma, in which type 2 helper T cell (Th2) activation is dominant, exposure to farm dust extracts (FDE) induces Th1/Th17 lung inflammation, associated with neutrophil infiltration. Macrophage influx is a common feature of both types of lung inflammation, allergic and nonallergic. Howeve...

One feature of allergic asthma, the EAR (early allergic reaction), is not present in the commonly used mouse models. We therefore investigated the mediators involved in EAR in a guinea-pig in vivo model of allergic airway inflammation. Animals were sensitized using a single OVA (ovalbumin)/alum injection and challenged with aerosolized OVA on day 14. On day 15, airway resistance was assessed af...

background: allergic rhinitis is one of the most common forms of allergic disorders affecting children. the prevalence rate of allergic rhinitis differs among countries and even among regions within the same country.   objectives: to determine the prevalence of childhood allergic rhinitis and the presence and significance of eosinophilia in nasal secretions.   method: 4584 children aged 11-15 y...

asthma is a complicated disorder, whose prevalence has increased over the past few decades.asthma is characterized by infiltration of inflammatory leukocytes along with enhancedproinflammatory cytokines and chemokines. fungi are now far more widely being considered as thedominant extrinsic trigger for asthma. fungi are linked to the severity of asthma in many ways. somedifferences between studi...

Background: Allergic diseases have increased during the past decade worldwide. Th2 type lymphocyte response is known to play an important role in the process of allergic inflammation. IL-4, a mediator of type II cytokine response increases IgE synthesis and Interferon gamma, a cytokine of type I response interferes with IL-4 and inhibits IgE production. Selenium is an essential component of glu...

background:  the development of allergic rhinitis (ar) is caused by the interaction between genetic predisposition and environmental factors. in this study, the association between gata3 single nucleotide polymorphisms and ar in an iranian population was identified. methods:  this case-control study was performed on 86 patients with ar and 86 healthy subjects. this study aimed to evaluate a pot...

a 47 year-old woman presented with eight-month history of tattoo allergic reaction of eyebrows after botulinum toxin a injection that was resistant to oral, topical and intralesional injection of corticosteroids. multiple sessions of treatment with co2 fractional laser resulted in significant flattening of allergic papules and plaques as well as reduction of tattoo pigmentation

background: allergic rhinitis (ar), the most prevalent allergic disease, has a rising trend in the world and has significantly impaired the quality of life of the patients. aeroallergens are the major cause of allergic rhinitis and among them pollens are the main allergens responsible for allergic rhinitis in iran

Background: Asthma and allergic rhinitis are among the most common diseases in the world. Objective: The aim of this study was to detect, by skin prick test, aeroallergens in allergic patients in Sari, Mazandaran in north of Iran. Methods: This is a prospective study of skin prick test of aeroallergens in asthma, allergic rhinitis and their combination with clinical diagnosis. Three hundred and...